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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injuryopen access

Authors
Lee, Jung IlPark, Ji HunKim, Yeong-RimGwon, KihakHwang, Hae WonJung, GayoungLee, Joo-YupSun, Jeong-YunPark, Jong WoongShin, Jae HoOk, Myoung-Ryul
Issue Date
Sep-2022
Publisher
Neural Regeneration Research
Keywords
crush injury; nerve injury; nerve regeneration; nitric oxide; peripheral nerve; revascularization; silica nanoparticles
Citation
Neural Regeneration Research, v.17, no.9, pp.2043 - 2049
Indexed
SCIE
SCOPUS
Journal Title
Neural Regeneration Research
Volume
17
Number
9
Start Page
2043
End Page
2049
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61058
DOI
10.4103/1673-5374.335160
ISSN
1673-5374
Abstract
Nitric oxide (NO) has been shown to promote revascularization and nerve regeneration after peripheral nerve injury. However, in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time scale. Recently, a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was introduced. In this study, NO-releasing silica nanoparticles (NO-SNs) were delivered to the peripheral nerves in rats after acute crush injury, mixed with natural hydrogel, to ensure the effective application of NO to the lesion. Microangiography using a polymer dye and immunohistochemical staining for the detection of CD34 (a marker for revascularization) results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic nerve. The sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated animals. Histological and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were increased. Moreover, muscle function recovery was improved in rats treated with NO-SNs. Taken together, our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury, thereby promoting axonal regeneration and improving functional recovery.
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Park, Jong Woong
Anam Hospital (Department of Orthopedic Surgery, Anam Hospital)
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