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Additive effects of coexisting respiratory comorbidities on overall or respiratory mortality in patients with asthma: a national cohort studyopen access

Authors
Yeo, YoomiLee, HyunRyu, JiinChung, Sung JunPark, Tai SunPark, Dong WonKim, Sang-HeonKim, Tae HyungSohn, Jang WonYoon, Ho JooMin, Kyung HoonMoon, Ji-Yong
Issue Date
May-2022
Publisher
Nature Publishing Group
Citation
Scientific Reports, v.12, no.1
Indexed
SCIE
SCOPUS
Journal Title
Scientific Reports
Volume
12
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61061
DOI
10.1038/s41598-022-12103-w
ISSN
2045-2322
2045-2322
Abstract
Asthmatic patients are generally considered to have an increased risk of mortality compared with subjects without asthma. However, this issue has been less evaluated using nationally representative data. Moreover, it is unclear whether respiratory comorbidities other than chronic obstructive pulmonary disease (COPD) are associated with increased mortality in asthmatic patients compared with subjects without. Using a nationally representative sample database, we performed a retrospective cohort study of patients with asthma and age-sex-matched control cohort. We estimated the hazard ratio (HR) and stratified the asthma cohort based on respiratory comorbidities. During a median 8.9-year follow-up, the overall mortality rate was higher in the asthma cohort than in the control cohort (p < 0.001). The hazard ratio (HR) for overall mortality in the asthma cohort compared with the control cohort was 1.13. The effects of asthma on overall mortality were more evident in males, patients under medical aid, and subjects with COPD. Respiratory comorbidities were significantly associated with increased risk of overall mortality in asthmatic patients compared with controls (adjusted HRs; 1.48 for COPD, 1.40 for bronchiectasis, 4.08 for lung cancer, and 1.59 for pneumonia). While asthma and lung cancer showed an additive effect only on overall mortality, asthma and other respiratory comorbidities (COPD, pneumonia, and bronchiectasis) had additive effects only on respiratory mortality. Patients with asthma had a higher overall mortality rate compared with subjects without asthma. Respiratory comorbidities showed an additive effect on overall or respiratory mortality in patients with asthma.
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Min, Kyung Hoon
Guro Hospital (Department of Pulmonary, Allergy, and Critical Care Medicine, Guro Hospital)
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