Risk of hypertension and treatment on out-of-hospital cardiac arrest incidence A case-control studyopen access
- Authors
- Kim, Jooyeong; Cho, Sung-il; Park, Jong-Hak; Song, Juhyun; Ahn, Sejoong; Cho, Hanjin; Moon, Sungwoo
- Issue Date
- Jun-2022
- Publisher
- Lippincott Williams & Wilkins Ltd.
- Keywords
- antihypertensive agent; hypertension; out-of-hospital cardiac arrest; prevention
- Citation
- Medicine, v.101, no.22
- Indexed
- SCIE
SCOPUS
- Journal Title
- Medicine
- Volume
- 101
- Number
- 22
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61064
- DOI
- 10.1097/MD.0000000000029161
- ISSN
- 0025-7974
1536-5964
- Abstract
- Hypertension (HTN) is a high risk factor for major cardiovascular adverse events. This study aimed to investigate the effect of HTN risk on out-of-hospital cardiac arrest (OHCA) incidence and determine whether the effect of HTN on OHCA incidence differs according to antihypertensive medication.
This case-control study used the Korean Cardiac Arrest Resuscitation Consortium and Korean Community Health Survey (CHS). Cases were defined as emergency medical service-treated adult OHCA patients presumed to have a cardiac etiology from 2015 to 2017. Patients without information on HTN diagnosis were excluded from the study. The Korean CHS database's controls were matched at a 1:2 ratio with strata, including age, gender, and county of residence. Multivariable conditional logistic regression analysis was conducted to estimate HTN risk and antihypertensive treatment on OHCA incidence,
A total of 2633 OHCA patients and 5266 community-based controls were enrolled in this study. Among them, 1176 (44.7%) patients and 2049 (38.9%) controls were diagnosed with HTN. HTN was associated with an increased risk of OHCA (adjusted odds ratio [AOR]: 1.19 [1.07–1.32]). On comparing HTN with or without the antihypertensive treatment group with the non-HTN-diagnosed group (as a reference), the HTN without treatment group had the highest AOR (95% confidence interval) (3.41 [2.74–4.24]). The AOR in the HTN treatment group was reduced to that in the non-HTN-diagnosed group (0.96 [0.86–1.08]).
HTN increased OHCA risk, and the HTN without treatment group had the highest OHCA risk. Conversely, OHCA risk decreased to the non-HTN-diagnosed group level with HTN treatment.
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Collections - 2. Clinical Science > Department of Emergency Medicine > 1. Journal Articles
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