Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Three-dimensional imaging for the analysis of human epidermal melanocytes

Authors
Kim, Dai HyunLee, Se JeongSeo, Soo HongAhn, Hyo HyunKim, Byung-JoSun, WoongRhyu, Im Joo
Issue Date
Sep-2022
Publisher
Basil Blackwell
Keywords
3-D imaging; melanocyte; nevus; skin-clearing technique; suction blister
Citation
Pigment Cell and Melanoma Research, v.35, no.5, pp 534 - 538
Pages
5
Indexed
SCIE
SCOPUS
Journal Title
Pigment Cell and Melanoma Research
Volume
35
Number
5
Start Page
534
End Page
538
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61102
DOI
10.1111/pcmr.13051
ISSN
1755-1471
1755-148X
Abstract
Three-dimensional (3-D) analysis of human epidermal melanocytes is required for deeper understanding of melanocytic disorders. The purpose of this study was to standardize 3-D imaging and quantification for the evaluation of epidermal melanocytes. The epidermal specimen was obtained using the suction blister method from a patient with melanocytic nevus on the forearm skin. Cutaneous ACT-PRESTO, the tissue-clearing and labeling technique, was subsequently performed. With the 3-D image analysis program, morphological reconstruction and quantification of selected perilesional and melanocytic nevus areas were possible. The region of melanocytic nevus showed higher numbers of total melanocytic dendrites and similar numbers of cell bodies compared with perilesional area. In addition, the mean area and volume of cell bodies increased in the melanocytic nevus area compared with the results in the perilesional area. The 3-D evaluation method of human epidermal melanocytes can be applied to investigate novel pathologies related to hyper- or hypo-pigmentary disorders.
Files in This Item
There are no files associated with this item.
Appears in
Collections
1. Basic Science > Department of Anatomy > 1. Journal Articles
2. Clinical Science > Department of Neurology > 1. Journal Articles
4. Research institute > Practical Anatomy Research Institute > 1. Journal Articles
2. Clinical Science > Department of Dermatology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Dai Hyun photo

Kim, Dai Hyun
Anam Hospital (Department of Dermatology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE