Alcoholic liver disease: a new insight into the pathogenesis of liver disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Seol Hee | - |
dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Sim, Jaemin | - |
dc.contributor.author | Seo, Seonkyung | - |
dc.contributor.author | Seo, Wonhyo | - |
dc.date.accessioned | 2022-07-11T02:40:16Z | - |
dc.date.available | 2022-07-11T02:40:16Z | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61145 | - |
dc.description.abstract | Excessive alcohol consumption contributes to a broad clinical spectrum of liver diseases, from simple steatosis to end-stage hepatocellular carcinoma. The liver is the primary organ that metabolizes ingested alcohol and is exquisitely sensitive to alcohol intake. Alcohol metabolism is classified into two pathways: oxidative and non-oxidative alcohol metabolism. Both oxidative and non-oxidative alcohol metabolisms and their metabolites have toxic consequences for multiple organs, including the liver, adipose tissue, intestine, and pancreas. Although many studies have focused on the effects of oxidative alcohol metabolites on liver damage, the importance of non-oxidative alcohol metabolites in cellular damage has also been discovered. Furthermore, extrahepatic alcohol effects are crucial for providing additional information necessary for the progression of alcoholic liver disease. Therefore, studying the effects of alcohol-producing metabolites and interorgan crosstalk between the liver and peripheral organs that express ethanol-metabolizing enzymes will facilitate a comprehensive understanding of the pathogenesis of alcoholic liver disease. This review focuses on alcohol-metabolite-associated hepatotoxicity due to oxidative and non-oxidative alcohol metabolites and the role of interorgan crosstalk in alcoholic liver disease pathogenesis. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한약학회 | - |
dc.title | Alcoholic liver disease: a new insight into the pathogenesis of liver disease | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12272-022-01392-4 | - |
dc.identifier.scopusid | 2-s2.0-85132903579 | - |
dc.identifier.wosid | 000817001400001 | - |
dc.identifier.bibliographicCitation | Archives of Pharmacal Research, v.45, no.7, pp 447 - 459 | - |
dc.citation.title | Archives of Pharmacal Research | - |
dc.citation.volume | 45 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 447 | - |
dc.citation.endPage | 459 | - |
dc.type.docType | Review; Early Access | - |
dc.identifier.kciid | ART002866521 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | ACID ETHYL-ESTERS | - |
dc.subject.keywordPlus | NONOXIDATIVE ETHANOL-METABOLISM | - |
dc.subject.keywordPlus | WHITE ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | BINGE ETHANOL | - |
dc.subject.keywordPlus | LUNG INJURY | - |
dc.subject.keywordPlus | GUT MICROBIOTA | - |
dc.subject.keywordPlus | STELLATE CELLS | - |
dc.subject.keywordPlus | POTENTIAL ROLE | - |
dc.subject.keywordPlus | RISK-FACTORS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordAuthor | Acetaldehyde | - |
dc.subject.keywordAuthor | Alcoholic liver disease | - |
dc.subject.keywordAuthor | Fatty acid ethyl esters | - |
dc.subject.keywordAuthor | Interorgan communication | - |
dc.subject.keywordAuthor | Non-oxidative alcohol metabolites | - |
dc.subject.keywordAuthor | Oxidative alcohol metabolites | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.