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High Expression of Claudin-4 Is Associated with Synchronous Tumors in Patients with Early Gastric Canceropen access

Authors
Kim, Won ShikKim, HayeonJoo, Moon KyungChoi, Byung IlYoo, Ah YoungPark, Jong-JaeLee, Beom JaeKim, Seung HanChun, Hoon Jai
Issue Date
Jun-2022
Publisher
MDPI AG
Keywords
claudin-4; early gastric cancer; synchronous neoplasms
Citation
Journal of Clinical Medicine, v.11, no.12
Indexed
SCIE
SCOPUS
Journal Title
Journal of Clinical Medicine
Volume
11
Number
12
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61149
DOI
10.3390/jcm11123550
Abstract
Claudin (CLDN) is a tight junction protein found in human epithelial cells and its altered expression is known to be associated with the progression of gastric cancer. We aimed to investigate the differential expression of CLDN-4 in early gastric cancer (EGC) according to its clinicopathological characteristics. We enrolled 53 patients with EGC who underwent surgical gastric resection from January 2007 to December 2018. The staining intensity of the tumor cells was scored as 0-3, and the percentage of staining was scored as 0-5; high expression was defined if the intensity plus percentage score was 7 or 8, and low expression was defined if the score was 0-6. Among the 53 patients, 16 (30.2%) showed low CLDN-4 expression, while 37 (69.8%) had high CLDN-4 expression. High CLDN-4 expression was significantly associated with intestinal-type EGC (low: 12.5% vs. high: 56.8%, p = 0.003), open-type atrophic change (low: 60.0% vs. high: 90.9%, p = 0.011), and the presence of synchronous tumors (0 vs. 32.4%, p = 0.010), and all 12 EGCs with synchronous tumors showed high CLDN-4 expression. However, expression of CLDN-3, a typical intestinal phenotype CLDN, was neither correlated with CLDN-4 expression nor associated with synchronous tumors. Taken together, high CLDN-4 expression may be considered as an auxiliary tool for screening synchronous tumors in patients with EGC.
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4. Research institute > Institute for Trauma Research > 1. Journal Articles
2. Clinical Science > Department of Pathology > 1. Journal Articles
2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles

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Park, Jong Jae
Guro Hospital (Department of Gastroenterology and Hepatology, Guro Hospital)
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