Prognostic Impact of Plasma Glucose on Patients With Cardiogenic Shock With or Without Diabetes Mellitus from the SMART RESCUE Trial
- Authors
- Choi, Seong Huan; Yoon, Gwang-Seok; Lee, Man-Jong; Park, Sang-Don; Ko, Young-Guk; Ahn, Chul-Min; Yu, Cheol Woong; Chun, Woo Jung; Jang, Woo Jin; Kim, Hyun-Joong; Kim, Bum Sung; Bae, Jang-Whan; Lee, Sang Yeub; Kwon, Sung Uk; Kim, Je Sang; Lee, Wang Soo; Jeong, Jin-Ok; Lim, Seong-Hoon; Cho, Sungsoo; Yang, Jeong Hoon; Gwon, Hyeon-Cheol
- Issue Date
- Jul-2022
- Publisher
- Excerpta Medica, Inc.
- Citation
- American Journal of Cardiology, v.175, pp 145 - 151
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- American Journal of Cardiology
- Volume
- 175
- Start Page
- 145
- End Page
- 151
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61163
- DOI
- 10.1016/j.amjcard.2022.04.008
- ISSN
- 0002-9149
1879-1913
- Abstract
- Although the presence of hyperglycemia has been shown to affect the clinical outcome of patients with cardiogenic shock, the extent of hyperglycemia and its association with prog-nosis have not been fully addressed in a large population. A total of 1,177 consecutive patients with cardiogenic shock were enrolled from January 2014 to December 2018 at 12 hospitals in South Korea. The primary outcome was in-hospital mortality. Patients were divided into 4 groups according to their initial plasma glucose level in patients with diabe-tes mellitus (DM) (n = 752) and patients without DM (n=425); group 1 (<= 8 mmol/L or 144 mg/100 ml), group 2 (8 to 12 mmol/L or 144 to 216 mg/100 ml), group 3 (12 to 16 mmol/L or 216 to 288 mg/100 ml), and group 4 (>= 16 mmol/L or 288 mg/100 ml). The groups with higher admission plasma glucose were associated with lower systolic blood pressure and higher lactic acid levels in patients with and without DM. In-hospital mortal-ity increased in groups with higher admission plasma glucose level in patients without DM (group 1:24.2%, group 2: 28.6%, group 3: 38.1%, group 4: 49.0%, p < 0.01), whereas in patients with DM, mortality and admission plasma glucose level showed no significant association (group 1: 45%, group 2: 35.4%, group 3: 33.3%, group 4: 43.1%, p = 0.26). Even after multivariate analysis, high plasma glucose was an independent predictor of in-hospital mortality in patients without DM. In patients with cardiogenic shock, plasma glu-cose obtained at admission was associated with in-hospital mortality in patients without DM.(C) 2022 Elsevier Inc. All rights reserved.
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