Familial Risk of Renal Cell Cancer and Interaction with Obesity and Hyperglycemia: A Population-Based Study
- Authors
- Lee, Sung Won; Kim, Hyun Jung; Kazmi, Sayada Zartasha; Choi, Yoon Jung; Hong, Gahwi; Kim, Young Shin; Eom, Jungmin; Swan, Heather; Cha, Jaewoo; Kang, Taeuk; Hann, Hoo Jae; Ahn, Hyeong Sik
- Issue Date
- Aug-2022
- Publisher
- Elsevier BV
- Keywords
- carcinoma; renal cell; gene-environment interaction; obesity; hyperglycemia
- Citation
- Journal of Urology, v.208, no.2, pp 251 - 258
- Pages
- 8
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Urology
- Volume
- 208
- Number
- 2
- Start Page
- 251
- End Page
- 258
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61247
- DOI
- 10.1097/JU.0000000000002506
- ISSN
- 0022-5347
1527-3792
- Abstract
- Purpose:
We quantified the familial risk of renal cell cancer (RCC) among first-degree relatives (FDRs) on a population level, and examined interactions between family history and body mass index or blood glucose.
Materials and Methods:
Using the National Health Insurance database, which covers the entire Korean population, and the National Health Screening Program, we constructed a cohort of 5,524,403 individuals with blood-related FDRs and their lifestyle factors from 2002 to 2018. We calculated familial risk using incidence risk ratios (IRRs) with 95% confidence intervals, which compares the risk of individuals with and without FDR. The combined effect and interaction of a given risk factor and family history of RCC were measured by the relative excess risk due to interaction.
Results:
Individuals with affected FDRs showed a 2.29-fold (95% CI 1.68–3.13) increased risk of disease. Familial risk adjusted for lifestyle factors showed minimal attenuation (IRR 2.25; 95% CI: 1.65–3.08), suggesting that genetic predisposition is the main contributor in the familial aggregation of RCC. Individuals with both a positive family history and overweight/obesity (IRR 3.71, 95% CI 2.50–4.92) or hyperglycemia (IRR 4.52, 95% CI 2.59–6.45) had a significantly higher risk that exceeded the sum of their individual risks, suggesting an interaction that was statistically significant (relative excess risk due to interaction 95% CI: 0.91, −0.21–2.12; 2.21, 0.28–4.14).
Conclusions:
Our findings suggest an interaction between genetic and environmental factors, namely obesity and hyperglycemia. Individuals with both factors should be considered a high-risk group and advised to undergo genetic counseling.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 1. Basic Science > Department of Preventive Medicine > 1. Journal Articles
- 3. Graduate School > Graduate School > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.