Endoscopic variceal obturation and retrograde transvenous obliteration for acute gastric cardiofundal variceal bleeding in liver cirrhosisopen access
- Lee, Han Ah; Kwak, Jungwon; Cho, Sung Bum; Lee, Young-Sun; Jung, Young Kul; Kim, Ji Hoon; Kim, Seung Up; An, Hyonggin; Yim, Hyung Joon; Yeon, Jong Eun; Seo, Yeon Seok
- Issue Date
- BioMed Central
- Rebleeding; Prevention; Balloon-occluded retrograde transvenous obliteration; Vascular plug-assisted retrograde transvenous obliteration; Portal hypertension
- BMC Gastroenterology, v.22, no.1
- Journal Title
- BMC Gastroenterology
We retrospectively compared the effect of endoscopic variceal obturation (EVO) and retrograde transvenous obliteration (RTO) in acute cardiofundal variceal bleeding.
Patients with acute cardiofundal variceal bleeding treated with EVO or RTO at two hospitals were included.
Ninety patients treated with EVO and 86 treated with RTO were analyzed. The mean model for end-stage liver disease score was significantly higher in EVO group than in RTO group (13.5 vs. 11.7, P = 0.016). The bleeding control rates were high (97.8% vs. 96.5%), and the treatment-related complication rates were low in both EVO and RTO groups (2.2% vs. 3.5%). During the median follow-up of 18.0 months, gastric variceal (GV) and esophageal variceal rebleeding occurred in 34 (19.3%) and 7 (4.0%) patients, respectively. The all-variceal rebleeding rates were comparable between EVO and RTO groups (32.4% vs. 20.8% at 2-year, P = 0.150), while the GV rebleeding rate was significantly higher in EVO group than in RTO group (32.4% vs. 12.8% at 2-year, P = 0.003). On propensity score-matched analysis (71 patients in EVO vs. 71 patients in RTO group), both all-variceal and GV rebleeding rates were significantly higher in EVO group than in RTO group (all P < 0.05). In Cox regression analysis, EVO (vs. RTO) was the only significant predictor of higher GV rebleeding risk (hazard ratio 3.132, P = 0.005). The mortality rates were similar between two groups (P = 0.597).
Both EVO and RTO effectively controlled acute cardiofundal variceal bleeding. RTO was superior to EVO in preventing all-variceal and GV rebleeding after treatment, with similar survival outcomes.
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- 1. Basic Science > Department of Biostatistics > 1. Journal Articles
- 2. Clinical Science > Department of Gastroenterology and Hepatology > 1. Journal Articles
- 2. Clinical Science > Department of Radiology > 1. Journal Articles
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