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The factor structure and clinical utility of clinician-rated dimensions of psychosis symptom severity in patients with recent-onset psychosis: Results of a 1-year longitudinal follow-up prospective cohort study

Authors
Jeong, Jae HoonKim, Sung-WanLee, Bong JuKim, Jung JinYu, Je-ChunWon, Seung-HeeLee, Seung-HwanKim, Seung-HyunKang, Shi HyunKim, EuitaeChung, Young-ChulLee, Kyu Young
Issue Date
Apr-2022
Publisher
Elsevier BV
Keywords
Recent-onset psychosis; DSM-5; Dimensions of psychosis; Schizophrenia subtype
Citation
Psychiatry Research, v.310
Indexed
SCIE
SSCI
SCOPUS
Journal Title
Psychiatry Research
Volume
310
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61302
DOI
10.1016/j.psychres.2022.114420
ISSN
0165-1781
Abstract
The classic subtype classification of schizophrenia has been removed, and DSM-5 now includes the Clinician-Rated Dimensions of Psychosis Symptom Severity (CRDPSS). In the present study, a factor analysis of the CRDPSS was performed, and we assessed whether patient classification using the derived factor structure helps predict the clinical course. The participants were 390 patients with recent-onset psychosis enrolled in the Korean Early Psychosis Cohort Study (KEPS). Two factors were identified: psychotic (including delusions, hallucinations, disorganization, and abnormal psychomotor behavior) and negative-cognitive (including negative symptoms and impaired cognition). Patients were grouped based on the factor structure and changes in clinical course were monitored over 1 year. The negative-cognitive group demonstrated longer duration of untreated psychosis, earlier onset, and a higher rate of psychiatric comorbidities. Baseline Positive and Negative Syndrome Scale (PANSS) total and Clinical Global Impression-Severity (CGI-S) scores were higher in psychotic group, but group differences were not observed after 2 months. Conversely, the PANSS negative scale score was significantly higher in negative-cognitive group throughout follow-up, and CGI-S score was reversed at 12 months. The findings indicate that the factor structure derived herein for the CRDPSS could be helpful for predicting the clinical course of recent-onset psychosis patients.
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Kim, Seung Hyun
Guro Hospital (Department of Psychiatry, Guro Hospital)
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