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Generation of human induced iPSC KUMi003-A from acute promyelocytic leukemia (APL) M3open access
- Issue Date
- Aug-2022
- Publisher
- Elsevier
- Citation
- Stem Cell Research, v.63
- Indexed
- SCIE
SCOPUS
- Journal Title
- Stem Cell Research
- Volume
- 63
- ISSN
- 1873-5061
1876-7753
- Abstract
- Acute promyelocytic leukemia (APL) M3 is an acute myeloid leukemia (AML) subtype and is characterized by the chromosomal translocation t(15;17)(p22;q11), which results in the fusion of the promyelocytic gene (PML) at 15q22 with the retinoic acid alpha-receptor gene (RARA) at 17q21. We generated an induced pluripotent stem cell line "KUMi003-A " from an APL M3 patient that is pluripotent and can differentiate into the three germ layers. This iPSC line will be useful as a disease model to investigate disease mechanisms specific to APL M3.
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Related Researcher
- Park, Yong
- Anam Hospital (Department of Medical Oncology and Hematology, Anam Hospital)