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Cited 2 time in webofscience Cited 2 time in scopus
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Somatic genomic landscape of East Asian epithelial ovarian carcinoma and its clinical implications from prospective clinical sequencing: A Korean Gynecologic Oncology Group study (KGOG 3047)

Authors
Sa, Jason K.Kim, JihyeKang, SokbomKim, Sang WunSong, TaejongShim, Seung-HyukChoi, Min ChulNo, Jae HongSong, Jae-YunKim, DeokhoonKim, Yong-ManKim, Jae-HoonLee, Jeong-Won
Issue Date
Oct-2022
Publisher
John Wiley & Sons Inc.
Keywords
cancer genome; epithelial ovarian carcinoma; next-generation sequencing; olaparib; personalized medicine
Citation
International Journal of Cancer, v.151, no.7, pp.1086 - 1097
Indexed
SCIE
SCOPUS
Journal Title
International Journal of Cancer
Volume
151
Number
7
Start Page
1086
End Page
1097
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61385
DOI
10.1002/ijc.34150
ISSN
0020-7136
Abstract
Through the wide adaptation of next-generation sequencing (NGS) technology within clinical practice, molecular profiling of the tumor has been the principal component of personalized treatment. In our study, we have generated a large collection of cancer genomes on East Asian epithelial ovarian carcinoma (EOC) patients and demonstrate the feasibility and utility of NGS platforms to explore the dynamic interrelations of major cancer driver alterations and their impacts on clinical prognosis and management. A total of 652 EOC patients have undergone clinical NGS panels to determine the prevalence of germline and somatic mutations. Notably, TP53 was the most frequently altered event (73%), followed by both BRCA1 and BRCA2 (22% each) and MYC (19%) through pan-EOC analysis. When analyzed based on individual histopathological levels, TP53 mutation was highly dominant in high-grade serous and mucinous histology, whereas mutations in PIK3CA and ARID1A were mostly observed in clear cell carcinoma, and KRAS, BRAF, and CDKN2A mutations were enriched in endometrioid, low-grade serous, and mucinous tumors, respectively. The network-based probabilistic model showed significant co-occurrences of TP53 with BRCA1 and ALK with BRCA2, NOTCH1, and ROS1, whereas mutual exclusivity of TP53 with KRAS and PIK3CA was evident. Furthermore, we utilized machine-learning algorithms to identify molecular correlates that conferred increased sensitivity to platinum and olaparib treatments including somatic mutations in BRCA1, ATM, and MYC. Conversely, patients with ALK mutation were considerably resistant to both treatment modalities. Collectively, our results demonstrate the clinical feasibility of prospective genetic sequencing to facilitate personalized treatment opportunities for patients with EOC.
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2. Clinical Science > Department of Obstetrics and Gynecology > 1. Journal Articles
3. Graduate School > Biomedical Research Center > 1. Journal Articles

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Song, Jae Yun
Anam Hospital (Department of Obstetrics and Gynecology, Anam Hospital)
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