Association between the interferon-gamma+874 T/A polymorphism and susceptibility to systemic lupus erythematosus and rheumatoid arthritis: A meta-analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- Dec-2022
- Publisher
- Blackwell Publishing Inc.
- Keywords
- IFN; meta-analysis; polymorphism; rheumatoid arthritis; systemic lupus erythematosus
- Citation
- International Journal of Immunogenetics, v.49, no.6, pp 365 - 371
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Immunogenetics
- Volume
- 49
- Number
- 6
- Start Page
- 365
- End Page
- 371
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61443
- DOI
- 10.1111/iji.12599
- ISSN
- 1744-3121
1744-313X
- Abstract
- We aimed to determine whether the interferon (IFN)-gamma +874 T/A polymorphism (rs2430561) is associated with susceptibility to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). A meta-analysis was conducted to assess the association between the IFN-gamma +874 T/A polymorphism and SLE or RA using allele contrast, homozygous contrast, recessive, and dominant models. A total of nine studies (six on SLE and three on RA), involving 1839 patients and 2272 controls, were included in the meta-analysis. The meta-analysis revealed a significant association between SLE and the TT genotype of the IFN-gamma +874 T/A polymorphism (odds ratio [OR] = 0.751, 95% confidence interval [CI] = 0.634-0.899, p = .001), and stratification by ethnicity indicated an association between the IFN-gamma +874 TT genotype and the Asian population. The analysis also revealed a significant association between SLE and the TT + TA genotype of the IFN-gamma +874 T/A polymorphism in Arab populations (OR = 1.598, 95% CI = 1.053-2.425, p = .028). However, no association between the IFN-gamma +874 T/A polymorphism and RA was found using allele contrast, recessive, dominant or homozygous contrast models in all study subjects and ethnic groups. This meta-analysis demonstrated that the IFN-gamma +874 T/A polymorphism is associated with susceptibility to SLE in Asian and Arab populations.
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- Appears in
Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
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