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Cited 5 time in webofscience Cited 6 time in scopus
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Taste Receptors beyond Taste Budsopen access

Authors
Ki, Su YoungJeong, Yong Taek
Issue Date
Sep-2022
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
taste; taste receptors; ectopic expression; tuft cells; G protein-coupled receptors
Citation
International Journal of Molecular Sciences, v.23, no.17
Indexed
SCIE
SCOPUS
Journal Title
International Journal of Molecular Sciences
Volume
23
Number
17
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61468
DOI
10.3390/ijms23179677
ISSN
1661-6596
1422-0067
Abstract
Taste receptors are responsible for detecting their ligands not only in taste receptor cells (TRCs) but also in non-gustatory organs. For several decades, many research groups have accumulated evidence for such "ectopic" expression of taste receptors. More recently, some of the physiologic functions (apart from taste) of these ectopic taste receptors have been identified. Here, we summarize our current understanding of these ectopic taste receptors across multiple organs. With a particular focus on the specialized epithelial cells called tuft cells, which are now considered siblings of type II TRCs, we divide the ectopic expression of taste receptors into two categories: taste receptors in TRC-like cells outside taste buds and taste receptors with surprising ectopic expression in completely different cell types.
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College of Medicine (Department of Pharmacology)
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