Utricular dysfunction in patients with orthostatic hypotension
- Authors
- Kim, Jae-Gyum; Lee, Jeong-Heon; Lee, Sun-Uk; Choi, Jeong-Yoon; Kim, Byung-Jo; Kim, Ji-Soo
- Issue Date
- Dec-2022
- Publisher
- Dr. Dietrich Steinkopff Verlag
- Keywords
- Orthostatic hypotension; Autonomic nervous system; Otolith
- Citation
- Clinical Autonomic Research, v.32, no.6, pp 431 - 444
- Pages
- 14
- Indexed
- SCIE
SCOPUS
- Journal Title
- Clinical Autonomic Research
- Volume
- 32
- Number
- 6
- Start Page
- 431
- End Page
- 444
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61508
- DOI
- 10.1007/s10286-022-00890-1
- ISSN
- 0959-9851
1619-1560
- Abstract
- Purpose
To delineate the association between otolithic dysfunction and orthostatic hypotension (OH).
Methods
We retrospectively reviewed the medical records of 382 patients who presented with orthostatic dizziness at a tertiary dizziness center between July 2017 and December 2021. Patients were included for analyses when they had completed ocular (oVEMP) and/or cervical vestibular-evoked myogenic potentials (cVEMP), and head-up tilt table test with a Finometer (n = 155). We compared the results between the patients with OH (n = 38) and those with NOI (normal head-up tilt table test despite orthostatic intolerance, n = 117).
Results
Thirty-eight patients with OH were further categorized as either classic (n = 30), delayed (n = 7), or initial (n = 1) types. Multivariable logistic regression showed that OH was associated with high baseline systolic BP (p = 0.046), presence of heart failure (p = 0.016), and unilateral oVEMP abnormalities (p = 0.016). n1 latency of oVEMP were negatively correlated with the maximal changes of systolic blood pressure (BP) in 15 s (ΔSBP15s, p = 0.013), 3 min (ΔSBP3min, p = 0.005) and 10 min (ΔSBP10min, p = 0.002). In contrast, the n1-p1 amplitude was positively correlated with ΔSBP15s (p = 0.029). Meanwhile, p13 latency of cVEMP was negatively correlated with ΔSBP10min (p = 0.018).
Conclusions
Our study provides evidence of utricular dysfunction related to OH.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Neurology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.