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Chronic exposure to butyl-paraben causes photosensitivity disruption and memory impairment in adult zebrafish

Authors
Kim, Jiwon L.Kim, Seong SoonHwang, Kyu-SeokPark, Hae-ChulCho, Sung-HeeBae, Myung AeKim, Ki-Tae
Issue Date
Oct-2022
Publisher
Elsevier BV
Keywords
Butyl-paraben; Neurotoxicity; Zebrafish; Behavior; Neurosteroid
Citation
Aquatic Toxicology, v.251
Indexed
SCIE
SCOPUS
Journal Title
Aquatic Toxicology
Volume
251
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61540
DOI
10.1016/j.aquatox.2022.106279
ISSN
0166-445X
Abstract
Limited studies on neurotoxicity following chronic exposure to butyl-paraben (BuP) have been conducted. In this study, neurobehavior in zebrafish adults was assessed using the novel tank test, photomotor response test, and T -maze test after exposure to BuP for 28 days at concentrations of 0, 0.01, 0.1, and 1.0 mg/L. To comprehensively understand the underlying molecular perturbations in the brain, alterations in transcripts, neurotransmitters, and neurosteroids were measured. We found that BuP penetrated the blood-brain barrier and impaired neuro-behavior in photosensitivity at 1.0 mg/L and in memory at 0.1 and 1.0 mg/L. RNA-seq analysis showed that phototransduction, tight junctions, and neuroactive ligand receptor activity were significantly affected, which explains the observed abnormal neurobehaviors. Neurosteroid analysis revealed that BuP increased cortisol levels in a concentration-dependent manner and specifically reduced allopregnanolone levels at all tested con-centrations, suggesting that cortisol and allopregnanolone are significant neurosteroid markers associated with photosensitivity and memory deficits. Collectively, we demonstrated that BuP can cross the blood-brain and modulate the levels of transcripts, associated with phototransduction and circadian rhythm, and neurosteroidal cortisol and allopregnanolone, resulting in abnormal neurobehavioral responses to light stimulation and learning and memory.
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