Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

PRE-Operative ECHOcardiograhy for prevention of cardiovascular events after non-cardiac surgery in intermediate- and high-risk patients: protocol for a low-interventional, mixed-cohort prospective study design (PREOP-ECHO)open access

Authors
Kim, Eun KyoungChoi, Hong-MiChoi, Eui-YoungLee, Hye SunPark, GoeunHan, Dong WooLee, Sang-EunPark, Chan SeokHwang, Ji-wonChoi, Jae HyukKim, Mi-NaKim, Hyung-KwanKim, Dae-HeeShin, Sung-HeeSohn, Il SukShin, Mi-SeungNa, Jin OhCho, IksungLee, Sun HwaPark, Yong HyunPark, Tae-HoKim, Kye HunCho, Goo-YoungJung, Hae OkPark, Dae-GyunHong, Ji YeonKang, Duk-Hyun
Issue Date
Sep-2022
Publisher
BioMed Central
Keywords
Echocardiography; Noncardiac surgery; Trial design
Citation
Trials, v.23, no.1
Indexed
SCIE
SCOPUS
Journal Title
Trials
Volume
23
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61543
DOI
10.1186/s13063-022-06701-2
Abstract
Background Cardiac evaluation using transthoracic echocardiography before noncardiac surgery is common in real-world practice. However, evidence supporting preoperative echocardiography is lacking. This study aims to evaluate the additional benefit of preoperative echocardiography in predicting postoperative cardiovascular events (CVE) in noncardiac surgery. Methods This study is designed as a multicenter, prospective study to assess the utility of preoperative echocardiography in patients undergoing intermediate- or high-risk noncardiac surgery. This trial comprises two studies: (1) a randomized controlled trial (RCT) for patients undergoing intermediate-risk surgery with fewer than three clinical risk factors from the revised cardiac risk index (intermediate-risk group) and (2) a prospective cohort study for patients undergoing intermediate-risk surgery with three or more clinical risk factors, or who undergo high-risk surgery regardless of the number of clinical risk factors (high-risk group). We hypothesize that the use of preoperative echocardiography will reduce postoperative CVEs in patients undergoing intermediate- to high-risk surgery through discovery of and further intervention for unexpected cardiac abnormalities before elective surgery. A total of 2330 and 2184 patients will be enrolled in the two studies. The primary endpoint is a composite of all-cause death; aborted sudden cardiac arrest; type I acute myocardial infarction; clinically diagnosed unstable angina; stress-induced cardiomyopathy; lethal arrhythmia, such as sustained ventricular tachycardia or ventricular fibrillation; and/or newly diagnosed or acutely decompensated heart failure within 30 days after surgery. Discussion This study will be the first large-scale prospective study examining the benefit of preoperative echocardiography in predicting postoperative CVE. The PREOP-ECHO trial will help doctors identify patients at risk of postoperative CVE using echocardiography and thereby reduce postoperative CVEs. Trial registration The Clinical Research Information Service KCT0006279 for RCT and KCT0006280 for prospective cohort study. Registered on June 21, 2021.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Cardiology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Mi na photo

Kim, Mi na
Anam Hospital (Department of Cardiology, Anam Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE