The Role of Matrix Metalloproteinase in Inflammation with a Focus on Infectious Diseasesopen access
- Authors
- Lee, Han Sol; Kim, Woo Joo
- Issue Date
- Sep-2022
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- influenza A virus; SARS-CoV-2; matrix metalloproteinases; infectious diseases
- Citation
- International Journal of Molecular Sciences, v.23, no.18
- Indexed
- SCIE
SCOPUS
- Journal Title
- International Journal of Molecular Sciences
- Volume
- 23
- Number
- 18
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61572
- DOI
- 10.3390/ijms231810546
- ISSN
- 1661-6596
1422-0067
- Abstract
- Matrix metalloproteinases (MMPs) are involved in extracellular matrix remodeling through the degradation of extracellular matrix components and are also involved in the inflammatory response by regulating the pro-inflammatory cytokines TNF-alpha and IL-1 beta. Dysregulation in the inflammatory response and changes in the extracellular matrix by MMPs are related to the development of various diseases including lung and cardiovascular diseases. Therefore, numerous studies have been conducted to understand the role of MMPs in disease pathogenesis. MMPs are involved in the pathogenesis of infectious diseases through a dysregulation of the activity and expression of MMPs. In this review, we discuss the role of MMPs in infectious diseases and inflammatory responses. Furthermore, we present the potential of MMPs as therapeutic targets in infectious diseases.
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- Appears in
Collections - 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
- 4. Research institute > Asian Pacific Influenza Institute > 1. Journal Articles
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