Detailed Information

Cited 4 time in webofscience Cited 3 time in scopus
Metadata Downloads

Augmented risk of ischemic stroke in hypertrophic cardiomyopathy patients without documented atrial fibrillationopen access

Authors
Choi, You-JungKim, BongseongRhee, Tae-MinLee, Hyun-JungLee, HeesunPark, Jun-BeanLee, Seung-PyoHan, Kyung-DoKim, Yong-JinKim, Hyung-Kwan
Issue Date
Sep-2022
Publisher
Nature Publishing Group
Citation
Scientific Reports, v.12, no.1
Indexed
SCIE
SCOPUS
Journal Title
Scientific Reports
Volume
12
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61612
DOI
10.1038/s41598-022-19895-x
ISSN
2045-2322
2045-2322
Abstract
Although atrial fibrillation (AF) is a well-established risk factor for ischemic stroke (IS) in hypertrophic cardiomyopathy (HCM), the risk of IS in HCM patients without documented AF is less recognized. This nationwide population-based cohort study using Korean National Health Insurance database included 8,328 HCM patients without documented AF and 1:2 propensity score-matched 16,656 non-HCM controls between 2010 and 2016. The primary outcome was an incident IS. During a mean follow-up of 6.1 years, IS occurred in 328/8,328 (3.9%) patients with HCM and 443/16,656 (2.7%) controls. The overall incidence of IS was 0.72/100 person-years in the HCM group, which was significantly higher than that in the control group (0.44/100 person-years) (HR 1.64; 95% CI 1.424-1.895; P < 0.001). The overall incidence of IS was 1.36/100 person-years in HCM patients aged >= 65 and 2.32/100 person-years years in those with heart failure, respectively. In the HCM group, age >= 65 years (adjusted HR 2.74; 95% CI 2.156-3.486; P < 0.001) and chronic heart failure (adjusted HR 1.75; 95% CI 1.101-2.745; P = 0.018) were independent risk factors for IS. HCM patients without documented AF are at a greater risk of IS, especially in those 65 years of age or older or those with chronic heart failure.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Cardiology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, You Jung photo

Choi, You Jung
Guro Hospital (Department of Cardiology, Guro Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE