Surgical outcomes of laparoscopic versus open hepatectomy for left hepatocellular carcinoma: Propensity score analyses using retrospective Japanese and Korean individual patient dataopen access
- Authors
- Kaibori, Masaki; Yoshii, Kengo; Umeda, Yuzo; Yagi, Takahito; Okabayashi, Takehiro; Sui, Kenta; Mori, Akira; Hamaguchi, Yuhei; Kajiyama, Kiyoshi; Hokuto, Daisuke; Monden, Kazuteru; Yoshizumi, Tomoharu; Nomura, Yoriko; Toriguchi, Kan; Kim, Jong Man; Choi, Gi Hong; Ryu, Je Ho; Koh, Yangseok; Kang, Koo Jeong; You, Young Kyoung; Chun, Kwang-Sik; Han, Young Seok; Cho, Chan Woo; Choi, Young Il; Kim, Dong-Sik; Yang, Jae Do; Mori, Keita; Hiraoka, Atsushi; Yamaue, Hiroki; Nakamura, Masafumi; Yamamoto, Masakazu; Endo, Itaru
- Issue Date
- Feb-2023
- Publisher
- Karger
- Keywords
- hepatocellular carcinoma; laparoscopic left hepatectomy; open left hepatectomy; postoperative complications; recurrence-free survival; overall survival
- Citation
- Liver Cancer, v.12, no.1, pp 32 - 43
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Liver Cancer
- Volume
- 12
- Number
- 1
- Start Page
- 32
- End Page
- 43
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61656
- DOI
- 10.1159/000527294
- ISSN
- 2235-1795
1664-5553
- Abstract
- Introduction: This study aimed to compare the prognostic impact of laparoscopic left hepatectomy (LLH) with that of open left hepatectomy (OLH) on patient survival after resection of left hepatocellular carcinoma (HCC).
Methods: Among the 953 patients who received initial treatment for primary HCC that was resectable by either LLH or OLH from 2013 to 2017 in Japan and Korea, 146 patients underwent LLH and 807 underwent OLH. The inverse probability of treatment weighting approach based on propensity scoring was used to address the potential selection bias inherent in the recurrence and survival outcomes between the LLH and OLH groups.
Results: The occurrence rate of postoperative complications and hepatic decompensation was significantly lower in the LLH group than in the OLH group. Recurrence-free survival (RFS) was better in the LLH group than in the OLH group (hazard ratio, 1.33; 95% confidence interval, 1.03-1.71; p = 0.029), whereas overall survival (OS) were not significantly different. Subgroup analyses of RFS and OS revealed an almost consistent trend in favor of LLH over OLH. In patients with tumor sizes of >= 4.0 cm or those with single tumors, both RFS and OS were significantly better in the LLH group than in the OLH group.
Conclusions: LLH decreases the risk of tumor recurrence and improves OS in patients with primary HCC located in the left liver.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Hepato-Biliary-Pancreatic Surgery > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.