Acute comitant strabismus in anti-GQ1b antibody syndrome
- Authors
- Lee, Sun-Uk; Baek, Seol-Hee; Kim, Hyo-Jung; Choi, Jeong-Yoon; Kim, Byung-Jo; Kim, Ji-Soo
- Issue Date
- Jan-2023
- Publisher
- Dr. Dietrich Steinkopff Verlag
- Keywords
- Diplopia; Nystagmus; Strabismus; Fisher syndrome
- Citation
- Journal of Neurology, v.270, no.1, pp 486 - 492
- Pages
- 7
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Neurology
- Volume
- 270
- Number
- 1
- Start Page
- 486
- End Page
- 492
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61662
- DOI
- 10.1007/s00415-022-11394-3
- ISSN
- 0340-5354
1432-1459
- Abstract
- Ophthalmoplegia is the diagnostic hallmark of anti-GQ1b antibody syndrome. This study aimed to define the patterns of acute comitant strabismus in patients with anti-GQ1b antibody syndromes. We retrospectively analyzed the ocular motor findings in 84 patients with anti-GQ1b antibody-associated ophthalmoplegia during the acute phases. Of the 84 patients, 11 (13%) showed acute comitant strabismus. Compared to those without, patients with acute comitant strabismus frequently showed abnormal ocular motor findings that included gaze-evoked (n = 8), spontaneous (n = 4) and positional nystagmus (n = 4), saccadic hypermetria (n = 3), head-shaking nystagmus (n = 2), pulse-step mismatch (n = 1), and impaired visual cancellation of the vestibulo-ocular reflex (n = 1, p < 0.001). On the contrary, iridoplegia (p = 0.029) and ptosis (p = 0.001) were more commonly observed in patients with paralytic (incomitant) strabismus than in those with acute comitant strabismus. Comitant strabismus can manifest during the acute phase of anti-GQ1b antibody syndromes in association with other central ocular motor abnormalities. These findings implicate that the cerebellum and/or brainstem can be the primary target of the anti-GQ1b antibodies.
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Collections - 2. Clinical Science > Department of Neurology > 1. Journal Articles
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