Statin use in patients with hormone receptor-positive metastatic breast cancer treated with everolimus and exemestaneopen access
- Authors
- Lee, Kyoungmin; Noh, Eunjin; Moon, Seok Joo; Joo, Yoonjung Yoonie; Kang, Eun Joo; Seo, Jae Hong; Park, In Hae
- Issue Date
- Mar-2023
- Publisher
- John Wiley and Sons Ltd
- Keywords
- breast neoplasm; estrogen receptor; everolimus; exemestane; hydroxymethylglutaryl-CoA reductase inhibitors
- Citation
- Cancer Medicine, v.12, no.5, pp 5461 - 5470
- Pages
- 10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cancer Medicine
- Volume
- 12
- Number
- 5
- Start Page
- 5461
- End Page
- 5470
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61721
- DOI
- 10.1002/cam4.5369
- ISSN
- 2045-7634
2045-7634
- Abstract
- Background
We analyzed the effect of statins in patients with hormone receptor-positive (HR+) metastatic breast cancer treated with everolimus + exemestane (EverX).
Materials and Methods
We conducted a nationwide retrospective cohort study using the National Health Insurance database with patients who received EverX for metastatic breast cancer between 2011 and 2019.
Results
Of 224,948 patients diagnosed with breast cancer, 1749 patients who received EverX for at least 30 days were included. Among them, 500 (28.6%) patients were found to take statins with EverX treatment (statin group), and the median duration of this combination was 5.36 months. The median time to treatment duration (TTD) for EverX and the overall survival (OS) were significantly higher in the statin group than in the no-statin group [7.69 vs. 5.06 months, p < 0.001; 45.7 vs. 26.0 months, p < 0.001, respectively]. Multivariable Cox analysis revealed that the use of statins was associated with prolonged TTD [HR = 0.67 (95% CI, 0.59–0.77)] and OS [HR = 0.57 (95% CI, 0.46–0.70)] for EverX even after adjustment for other covariates.
Conclusion
Statins may have synergistic effects with endocrine therapy with the mTOR inhibitor everolimus, and improve survival in patients with HR+ metastatic breast cancer.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Medical Oncology and Hematology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.