Serological Evidence of Severe Fever with Thrombocytopenia Syndrome Virus and IgM Positivity Were Identified in Healthy Residents in Vietnamopen access
- Authors
- Tran, Xuan Chuong; Kim, Sung Hye; Lee, Jeong-Eun; Kim, So-Hee; Kang, Su Yeon; Nguyen, D. Binh; Pham, V. Duc; Phan, T. K. Phuong; Nguyen, T. P. Thao; Lee, Wonwoo; Bae, Joon-Yong; Park, Man-Seong; Kim, Misun; Yoo, Jeong Rae; Heo, Sang Taek; An, Kyeong Ho; Kim, Jung Mogg; Cho, Nam-Hyuk; Kee, Sun-Ho; Lee, Keun Hwa
- Issue Date
- Oct-2022
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- severe fever with thrombocytopenia syndrome virus (SFTSV); serological evidence; IgM positivity; healthy residents; Vietnam
- Citation
- Viruses, v.14, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Viruses
- Volume
- 14
- Number
- 10
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61776
- DOI
- 10.3390/v14102280
- ISSN
- 1999-4915
1999-4915
- Abstract
- Severe fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne viral disease, is prevalent in East Asia and has also been reported in Southeast Asia since 2019. SFTS patients in Vietnam were first reported in 2019. However, the seroprevalence of severe fever with thrombocytopenia syndrome virus (SFTSV) in Vietnam has not been reported. To investigate the seroprevalence of SFTSV in Vietnam, we collected serum samples from 714 healthy residents in Thua Thien Hue and Quang Nam Province, Vietnam, and the seroprevalence of SFTSV was assessed using immunofluorescence antibody assay (IFA), Enzyme-Linked Immunosorbent Assays (ELISAs) and the 50% focus reduction neutralization test (FRNT50) assay. The seroprevalence of anti-SFTSV IgM or IgG was observed to be 3.64% (26/714), high IgM positivity was >80 (0.28%, 2/714) and the titer of neutralizing antibodies against SFTSV ranged from 15.5 to 55.9. In Pakistan, SFTSV infection confirmed using a microneutralization test (MNT) assay (prevalence is 2.5%) and ELISAs showed a high seroprevalence (46.7%) of SFTSV. Hence, the seroprevalence rate in Vietnam is similar to that in Pakistan and the number of SFTS patients could increase in Vietnam.
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- Appears in
Collections - 1. Basic Science > Department of Microbiology > 1. Journal Articles
- 4. Research institute > Institute for Viral Diseases > 1. Journal Articles
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