The Association Between the PTPN22 C1858T Variant and Vasculitis: A Meta-analysis Update with Trial Sequential Analysis
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- Oct-2022
- Publisher
- Mary Ann Liebert Inc.
- Keywords
- vasculitis; protein tyrosine phosphatase nonreceptor 22; variant; meta-analysis
- Citation
- Genetic Testing and Molecular Biomarkers, v.26, no.10, pp 492 - 500
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Genetic Testing and Molecular Biomarkers
- Volume
- 26
- Number
- 10
- Start Page
- 492
- End Page
- 500
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61796
- DOI
- 10.1089/gtmb.2022.0119
- ISSN
- 1945-0265
1945-0257
- Abstract
- Objective: The present study was designed to determine whether the protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T variant is associated with susceptibility to vasculitis.
Methods: A meta-analysis was conducted to evaluate the association between the PTPN22 C1858T variant and vasculitis. A trial sequential analysis was performed to evaluate the robustness of the meta-analysis.
Results: A total of 17 studies were included in this meta-analysis which revealed a highly significant association between the PTPN22 T allele and vasculitis of multiple types (odds ratio [OR] = 4.850, 95% confidence interval [CI] = 3.043–7.729, p < 0.001). Meta-analysis by vasculitis type showed an association between the T allele and risk of giant cell arteritis (GCA) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV) (OR = 7.505, 95% CI = 3.605–15.62, p < 0.001; OR = 6.121, 95% CI = 3.216–11.65, p < 0.001). The meta-analysis also indicated an association between the T allele and Takayasu's arteritis, but not between the T allele and Behcet's disease or Henoch–Schönlein purpura. TSA indicated that the observed association is conclusive with the existing evidence.
Conclusions: This meta-analysis confirms that the PTPN22 C1858T variant is associated with susceptibility to GCA and AAV.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.