Photoswitchable Microgels for Dynamic Macrophage Modulation
- Authors
- Kim, Yuri; Thangam, Ramar; Yoo, Jounghyun; Heo, Jeongyun; Park, Jung Yeon; Kang, Nayeon; Lee, Sungkyu; Yoon, Jiwon; Mun, Kwang Rok; Kang, Misun; Min, Sunhong; Kim, Seong Yeol; Son, Subin; Kim, Jihwan; Hong, Hyunsik; Bae, Gunhyu; Kim, Kanghyeon; Lee, Sanghyeok; Yang, Letao; Lee, Ja Yeon; Kim, Jinjoo; Park, Steve; Kim, Dong-Hyun; Lee, Ki-Bum; Jang, Woo Young; Kim, Bong Hoon; Paulmurugan, Ramasamy; Cho, Seung-Woo; Song, Hyun-Cheol; Kang, Seok Ju; Sun, Wujin; Zhu, Yangzhi; Lee, Junmin; Kim, Han-Jun; Jang, Ho Seong; Kim, Jong Seung; Khademhosseini, Ali; Kim, Yongju; Kim, Sehoon; Kang, Heemin
- Issue Date
- Oct-2022
- Publisher
- John Wiley and Sons Ltd
- Keywords
- dynamic hydrogels; macrophage adhesion; macrophage polarization; microgel swelling; photoswitchable microgels
- Citation
- Advanced Materials, v.34, no.49
- Indexed
- SCIE
SCOPUS
- Journal Title
- Advanced Materials
- Volume
- 34
- Number
- 49
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61819
- DOI
- 10.1002/adma.202205498
- ISSN
- 0935-9648
1521-4095
- Abstract
- Dynamic manipulation of supramolecular self-assembled structures is achieved irreversibly or under non-physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via pi-cation and pi-pi interactions are developed that are electrostatically stabilized with Arg-Gly-Asp (RGD)-bearing anionic polymers. Lateral swelling of RGD-bearing microgels occurs via cis-azobenzene formation mediated by near-infrared-light-upconverted ultraviolet light, which disrupts intermolecular interactions on the visible-light-absorbing upconversion-nanoparticle-coated materials. Real-time imaging and molecular dynamics simulations demonstrate the deswelling of RGD-bearing microgels via visible-light-mediated trans-azobenzene formation. Near-infrared light can induce in situ swelling of RGD-bearing microgels to increase RGD availability and trigger release of loaded interleukin-4, which facilitates the adhesion structure assembly linked with pro-regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD-bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro-inflammatory polarization. These microgels exhibit high stability and non-toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells.
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Collections - 2. Clinical Science > Department of Orthopedic Surgery > 1. Journal Articles
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