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Tamalin Function Is Required for the Survival of Neurons and Oligodendrocytes in the CNSopen access

Authors
Seo, YongboMo, SeojungKim, SuhyunKim, HyunPark, Hae-Chul
Issue Date
Nov-2022
Publisher
MDPI
Keywords
tamalin; arf6; neurodegeneration; oligodendrocytes; mGluR5; zebrafish; mice
Citation
International Journal of Molecular Sciences, v.23, no.21
Indexed
SCIE
SCOPUS
Journal Title
International Journal of Molecular Sciences
Volume
23
Number
21
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61843
DOI
10.3390/ijms232113395
ISSN
1661-6596
1422-0067
Abstract
Tamalin is a post-synaptic scaffolding protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) and several other proteins involved in protein trafficking and cytoskeletal events, including neuronal growth and actin reorganization. It plays an important role in synaptic plasticity in vitro by controlling the ligand-dependent trafficking of group 1 mGluRs. Abnormal regulation of mGluRs in the central nervous system (CNS) is associated with glutamate-mediated neurodegenerative disorders. However, the pathological consequences of tamalin deficiency in the CNS are unclear. In this study, tamalin knockout (KO) zebrafish and mice exhibited neurodegeneration along with oligodendrocyte degeneration in the post-embryonic CNS to adulthood without any developmental defects, thus suggesting the function of tamalin is more important in the postnatal stage to adulthood than that in CNS development. Interestingly, hypomyelination was independent of axonal defects in the CNS of tamalin knockout zebrafish and mice. In addition, the loss of Arf6, a downstream signal of tamalin scaffolding protein, synergistically induced neurodegeneration in tamalin KO zebrafish even in the developing CNS. Furthermore, tamalin KO zebrafish displayed increased mGluR5 expression. Taken together, tamalin played an important role in neuronal and oligodendrocyte survival and myelination through the regulation of mGluR5 in the CNS.
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1. Basic Science > Department of Anatomy > 1. Journal Articles
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