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Impact of COVID-19 Pandemic on Management and Outcomes in Patients with Septic Shock in the Emergency Departmentopen access

Authors
Jeong, DaunLee, Gun TakPark, Jong EunShin, Tae GunKim, KyungaJang, DoeunKim, Won YoungJo, You HwanChung, Sung PhilBeom, Jin HoChoi, Sung-HyukKwon, Woon YongSuh, Gil JoonKo, Byuk SungHan, Kap SuShin, Jong HwanCho, HanjinKorean Shock Society InvestigatorsHwang, Sung Yeon
Issue Date
Nov-2022
Publisher
MDPI AG
Keywords
COVID-19; septic shock; resuscitation; sepsis bundle; mortality
Citation
Journal of Personalized Medicine, v.12, no.11
Indexed
SCIE
SCOPUS
Journal Title
Journal of Personalized Medicine
Volume
12
Number
11
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61856
DOI
10.3390/jpm12111803
ISSN
2075-4426
Abstract
This study aimed to determine the impact of modifications in emergency department (ED) practices caused by the coronavirus disease 2019 (COVID-19) pandemic on the clinical outcomes and management of patients with septic shock. We performed a retrospective study. Patients with septic shock who presented to the ED between 1 January 2018 and 19 January 2020 were allocated to the pre-COVID-19 group, whereas those who presented between 20 January 2020 and 31 December 2020 were assigned to the post-COVID-19 group. We used propensity score matching to compare the sepsis-related interventions and clinical outcomes. The primary outcome measure was in-hospital mortality. Of the 3697 patients included, 2254 were classified as pre-COVID-19 and 1143 as postCOVID-19. A total of 1140 propensity score-matched pairings were created. Overall, the in-hospital mortality rate was 25.5%, with no statistical difference between the pre- and post-COVID-19 groups (p = 0.92). In a matched cohort, the post-COVID-19 group had delayed lactate measurement, blood culture test, and infection source control (all p < 0.05). There was no significant difference in time to antibiotics (p = 0.19) or vasopressor administration (p = 0.09) between the groups. Although sepsis-related interventions were delayed during the COVID-19 pandemic, there was no significant difference in the in-hospital mortality between the pre- and post-COVID-19 groups.
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Cho, Han Jin
Ansan Hospital (Department of Emergency Medicine, Ansan Hospital)
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