Identification of a Novel Long Non-coding RNA, lnc-ATMIN-4:2, and its Clinicopathological and Prognostic Significance in Advanced Gastric Cancer
- Authors
- Kim, Eojin; Kim, Hyunjin; Yeo, Min-Kyung; Kim, Chul Hwan; Kim, Joo Young; Park, Sungsoo; Kim, Hyun-Soo; Chae, Yang-Seok
- Issue Date
- Nov-2022
- Publisher
- International Institute of Anticancer Research
- Keywords
- Stomach cancer; advanced gastric cancer; long non-coding RNA; lnc-ATMIN-4:2; whole transcriptome sequencing; RNA in situ hybridization; prognosis
- Citation
- Cancer Genomics and Proteomics, v.19, no.6, pp 761 - 772
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cancer Genomics and Proteomics
- Volume
- 19
- Number
- 6
- Start Page
- 761
- End Page
- 772
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/61936
- DOI
- 10.21873/cgp.20358
- ISSN
- 1109-6535
1790-6245
- Abstract
- Background/Aim: Long non-coding RNAs (lncRNAs) are emerging as significant regulators of gene expression and a novel promising biomarker for cancer diagnosis and prognosis. This study identified a novel, differentially expressed lncRNA in advanced gastric cancer (AGC), Inc-ATMIN-4:2, and evaluated its clinicopathological and prognostic significance.
Patients and Methods: Whole transcriptome sequencing was performed to identify differentially expressed lncRNAs in AGC tissue samples. We also analyzed lnc-ATMIN-4:2 expression in 317 patients with AGC using RNA in situ hybridization.
Results: High (>30 dots) lnc-ATMIN-4:2 expression significantly correlated with younger age, poorly differentiated histology, diffuse type, deeper invasion depth, perineural invasion, lymph node metastasis, and higher stage group. In addition, high lnc-ATMIN-4:2 expression was significantly associated with worse overall survival in patients with AGC.
Conclusion: This study elucidated the significance of lncRNAs in AGC and indicated the value of lnc-ATMIN-4:2 expression as a predictive biomarker for the overall survival of patients with AGC.
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Collections - 2. Clinical Science > Department of Foregut Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Pathology > 1. Journal Articles
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