Major Adverse Cardiovascular Events in Korean Congenital Heart Disease Patients: A Nationwide Age- and Sex-Matched Case-Control Studyopen access
- Authors
- Lee, Jue Seong; Jung, Jin-Man; Choi, Jongun; Seo, Woo-Keun; Shin, Hong Ju
- Issue Date
- Dec-2022
- Publisher
- 연세대학교의과대학
- Keywords
- Congenital heart disease; vascular events; all-cause mortality; Korean nationwide study
- Citation
- Yonsei Medical Journal, v.63, no.12, pp 1069 - 1077
- Pages
- 9
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Yonsei Medical Journal
- Volume
- 63
- Number
- 12
- Start Page
- 1069
- End Page
- 1077
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62015
- DOI
- 10.3349/ymj.2022.0111
- ISSN
- 0513-5796
1976-2437
- Abstract
- Purpose
Congenital heart disease (CHD) is a known risk factor for acquired cardiovascular and cerebrovascular diseases. However, available evidence on CHD is limited mostly to Western populations. This study aimed to evaluate the prevalence of vascular events and all-cause mortality in Korean patients with CHD and to further corroborate CHD as a predictor of vascular events and all-cause mortality.
Materials and Methods
The claims data of the Korean National Health Insurance Service (NHIS) were retrospectively reviewed. Information regarding diagnostic codes, comorbidities, medical services, income level, and residential area was also collected. Outcomes of interest included stroke, myocardial infarction (MI), all-cause mortality, and major adverse cardiovascular events (MACE).
Results
We included 232203 patients with CHD and 3024633 individuals without CHD as a control group through age- and sex-matched 1:10 random sampling. The prevalences of hypertension, congestive heart failure, ischemic heart disease, hyperlipidemia, and atrial fibrillation were significantly higher in the CHD group, which had a more than two-fold higher incidence of vascular events and all-cause mortality, than in the group without CHD. Multivariable models demonstrated that CHD was a significant risk factor for stroke, MI, all-cause mortality, and MACE.
Conclusion
In conclusion, this nationwide study demonstrates that Korean patients with CHD have a high incidence of comorbidities, vascular events, and mortality. CHD has been established as an important predictor of cardiovascular events. Further studies are warranted to identify high-risk patients with CHD and related factors to prevent vascular events.
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- Appears in
Collections - 2. Clinical Science > Department of Thoracic and Cardiovascular Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Neurology > 1. Journal Articles
- 2. Clinical Science > Department of Pediatrics > 1. Journal Articles
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