Is the platelet function test effective in predicting blood loss in patients undergoing hepatic resection?
- Authors
- Gwon, Jun Gyo; Ko, Sun-Young; Kim, Hyokee
- Issue Date
- Oct-2022
- Publisher
- 대한외과학회
- Keywords
- Bleeding; Hepatectomy; Liver; Platelet function tests
- Citation
- Annals of Surgical Treatment and Research, v.103, no.4, pp 227 - 234
- Pages
- 8
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Annals of Surgical Treatment and Research
- Volume
- 103
- Number
- 4
- Start Page
- 227
- End Page
- 234
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62070
- DOI
- 10.4174/astr.2022.103.4.227
- ISSN
- 2288-6575
2288-6796
- Abstract
- Purpose
The platelet function analyzer (PFA)-100/200 is widely used to assess platelet function. However, its role in predicting the perioperative risk of bleeding in patients undergoing liver resection remains controversial. Therefore, we aimed to ascertain whether the platelet function test could be useful in predicting bleeding risk in patients undergoing hepatic surgery.
Methods
The study participants were patients who underwent hepatectomy for hepatocellular carcinoma at our hospital over a period of 10 years from January 1, 2010 to May 31, 2020. PFA-200 values of these patients were divided into 2 groups; normal (n = 333) and prolonged (n = 39).
Results
There were no significant differences regarding the volumes of calculated blood loss during surgery between the normal and prolonged PFA groups (879.55 ± 1,046.50 mL vs. 819.74 ± 912.64 mL, respectively; P = 0.733); intraoperative RBC transfusion (0.52 ± 2.02 units vs. 0.26 ± 1.02 units, P = 0.419) and postoperative RBC transfusion (0.24 ± 1.17 units vs. 0.46 ± 1.97 units, P = 0.306) were similar between the 2 groups, respectively. Multivariate analysis revealed no association between PFA closure time and calculated blood loss (hazard ratio, 1.06; P = 0.881). Moreover, there was no association between PFA closure time and preoperative laboratory results or assessment of tool-related liver function in multivariate analysis.
Conclusion
There was no correlation between the amount of blood loss and platelet function in patients who underwent liver resection. In patients undergoing liver resection who are not managed on antiplatelet agents or do not have chronic kidney disease, the use of routine PFA is not recommended.
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- Appears in
Collections - 2. Clinical Science > Department of Transplantation and Vascular Surgery > 1. Journal Articles
- 2. Clinical Science > Department of Laboratory Medicine > 1. Journal Articles
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