Relative Effectiveness of COVID-19 Vaccination in Healthcare Workers: 3-Dose Versus 2-Dose Vaccinationopen access
- Authors
- Kim, Sung Ran; Kang, Hyeon Jeong; Jeong, Hye Rin; Jang, Su Yeon; Lee, Jae Eun; Kim, Da Eun; Lee, Hae Ry; Cho, Min Hee; Noh, Ji Yun; Cheong, Hee Jin; Kim, Woo Joo; Song, Joon Young
- Issue Date
- Sep-2022
- Publisher
- 대한의학회
- Keywords
- SARS-CoV-2; COVID-19; Healthcare Worker; Vaccine Effectiveness
- Citation
- Journal of Korean Medical Science, v.37, no.35
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Journal of Korean Medical Science
- Volume
- 37
- Number
- 35
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62083
- DOI
- 10.3346/jkms.2022.37.e267
- ISSN
- 1011-8934
1598-6357
- Abstract
- The omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to have high infectivity and is more likely to evade vaccine immunity. However, booster vaccination is expected to strengthen cross-reactive immunity, thereby increasing the vaccine effectiveness (VE). This study aimed to evaluate the relative VE of the 3-dose (booster) vaccination compared with the 2-dose primary series vaccination in healthcare workers during omicron variant-dominant periods. During the omicron-dominant period from February 1, 2022 to February 28, 2022, a 1:1 matched case-control study was conducted.
Healthcare workers with positive SARS-CoV-2 test results were classified as positive cases, whereas those with negative results served as controls. Compared with the 2-dose primary series vaccination, booster vaccination with mRNA vaccine showed moderate VE (53.1%).
However, in multivariate analysis including the time elapsed after vaccination, the significant VE disappeared, reflecting the impact of recent vaccination rather than the third dose itself.
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- Appears in
Collections - 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
- 5. Others > Hospital Epidemiology & Infection Control Unit > 1. Journal Articles
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