Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster modelsopen access
- Authors
- Jeong, Haengdueng; Lee, Youn Woo; Park, In Ho; Noh, Hyuna; Kim, Sung-Hee; Kim, Jiseon; Jeon, Donghun; Jang, Hui Jeong; Oh, Jooyeon; On, Dain; Uhm, Chanyang; Cho, Kyungrae; Oh, Heeju; Yoon, Suhyeon; Seo, Jung Seon; Kim, Jeong Jin; Seok, Sang-Hyuk; Lee, Yu Jin; Hong, Seung-Min; An, Se-Hee; Kim, Seo Yeon; Kim, Young Been; Hwang, Ji-Yeon; Lee, Hyo-Jung; Kim, Hong Bin; Jeong, Dae Gwin; Song, Daesub; Song, Manki; Park, Man-Seong; Choi, Kang-Seuk; Park, Jun Won; Seo, Jun-Young; Yun, Jun-Won; Shin, Jeon-Soo; Lee, Ho-Young; Nam, Ki Taek; Seong, Je Kyung
- Issue Date
- Nov-2022
- Publisher
- The Company of Biologists Ltd.
- Keywords
- SARS-CoV-2; Syrian golden hamster; K18-hACE2 mice
- Citation
- DMM Disease Models and Mechanisms, v.15, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- DMM Disease Models and Mechanisms
- Volume
- 15
- Number
- 11
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62115
- DOI
- 10.1242/dmm.049632
- ISSN
- 1754-8403
1754-8411
- Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiological agent of COVID-19, causes life-threatening disease. This novel coronavirus enters host cells via the respiratory tract, promoting the formation of severe pulmonary lesions and systemic disease. Few animal models can simulate the clinical signs and pathology of COVID-19 patients. Diverse preclinical studies using K18-hACE2 mice and Syrian golden hamsters, which are highly permissive to SARS-CoV-2 in the respiratory tract, are emerging; however, the systemic pathogenesis and cellular tropism of these models remain obscure. We intranasally infected K18-hACE2 mice and Syrian golden hamsters with SARS-CoV-2, and compared the clinical features, pathogenesis, cellular tropism and infiltrated immune-cell subsets. In K18-hACE2 mice, SARS-CoV-2 persistently replicated in alveolar cells and caused pulmonary and extrapulmonary disease, resulting in fatal outcomes. Conversely, in Syrian golden hamsters, transient SARS-CoV-2 infection in bronchial cells caused reversible pulmonary disease, without mortality. Our findings provide comprehensive insights into the pathogenic spectrum of COVID-19 using preclinical models.
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- Appears in
Collections - 1. Basic Science > Department of Microbiology > 1. Journal Articles
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