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Association between physical activity and risk of renal function decline and mortality in community-dwelling older adults: a nationwide population-based cohort studyopen access

Authors
Kim, HyunsukKo, Mun JungLim, Chi-YeonBae, EunjinHyun, Young YoulChung, SungjinKwon, Soon HyoCho, Jang-HeeYoo, Kyung DonPark, Woo YeongSun, In O.Yu, Byung ChulKo, Gang-JeeYang, Jae WonHwang, Won MinSong, Sang HeonShin, Sung JoonHong, Yu Ah
Issue Date
Dec-2022
Publisher
BioMed Central
Keywords
Physical activity; Renal function; Mortality; Older adults
Citation
BMC Geriatrics, v.22, no.1
Indexed
SCIE
SSCI
SCOPUS
Journal Title
BMC Geriatrics
Volume
22
Number
1
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62292
DOI
10.1186/s12877-022-03693-1
ISSN
1471-2318
Abstract
Background Physical activity (PA) is an important risk factor associated with health outcomes. However, the relationship between PA and kidney function decline in older adults remains unclear. We examined the influence of PA on kidney function decline and mortality in community-dwelling older adults. Methods Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m2 who had available health checkup data from 2009 to 2010 were included. The cohort was followed annually through December 2015 for anthropometric, sociodemographic, and medical information including outcomes and biennially for laboratory information from the health checkup. We divided these patients into three groups according to self-reported PA (Inactive group: no leisure-time PA, Active group: vigorous activity for at least 80 min/week or a sum of moderate-intensity activity and walking for at least 300 min/week, Low-active group: level of PA between the definitions of the other two groups). Associations between the intensity of PA and death, cardiovascular death, and ≥ 50% eGFR decline were investigated. Results Among 102,353 subjects, 32,984 (32.23%), 54,267 (53.02%), and 15,102 (14.75%) were classified into the inactive, low-active, and active groups, respectively. The active group was younger, contained a higher proportion of men, and had higher frequencies of hypertension, diabetes mellitus, drinking, and smoking than the other groups. The active group had significantly lower incidence rates of mortality, cardiovascular mortality, and kidney function decline than the other groups (all p < 0.001). The active group also showed lower all-cause (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.70–0.82) and cardiovascular mortality (HR, 0.64; 95% CI, 0.53–0.78) and protection against ≥ 50% eGFR decline (HR, 0.81; 95% CI, 0.68–0.97) compared with the inactive group in the fully adjusted Cox proportional hazards regression model. Conclusions High PA was an independent modifiable lifestyle factor for reducing mortality and protecting against declines in kidney function in older adults.
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Ko, Gang Jee
Guro Hospital (Department of Nephrology and Hypertension, Guro Hospital)
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