Diagnostic Efficacy of Serum Asialo alpha 1-Acid Glycoprotein Levels for Advanced Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Compared to That in Healthy Subjects: A Prospective Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yoonseok | - |
dc.contributor.author | Bae, Seryun | - |
dc.contributor.author | Kim, Ji Hoon | - |
dc.contributor.author | Kwak, Minjung | - |
dc.contributor.author | Jeon, So Yeon | - |
dc.contributor.author | Kim, Taehyung | - |
dc.contributor.author | Yim, Sun Young | - |
dc.contributor.author | Lee, Young-Sun | - |
dc.contributor.author | Jung, Young Kul | - |
dc.contributor.author | Seo, Yeon Seok | - |
dc.contributor.author | Yim, Hyung Joon | - |
dc.contributor.author | Yeon, Jong Eun | - |
dc.contributor.author | Byun, Kwan Soo | - |
dc.date.accessioned | 2023-02-14T00:40:07Z | - |
dc.date.available | 2023-02-14T00:40:07Z | - |
dc.date.issued | 2023-01 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62367 | - |
dc.description.abstract | Background Serum asialo alpha 1-acid gycoprotein (AsAGP) is a novel biomarker specific to liver fibrosis. Aim To evaluate the diagnostic efficacy of serum AsAGP levels in classifying the severity of liver fibrosis and differentiating liver cirrhosis (LC) in patients with chronic hepatitis B (CHB) from healthy controls. Methods Overall, 206 subjects were prospectively enrolled. LC was diagnosed based on liver stiffness levels (>11 kPa) measured using transient elastography. Serum AsAGP levels were measured using an antibody-lectin sandwich immunoassay. We investigated the diagnostic performance by comparing serum AsAGP levels among healthy control, CHB, and CHB with LC groups. Sensitivity, specificity, and optimal AsAGP cut-off values were also calculated. Results Serum AsAGP levels were significantly different between healthy controls, CHB patients, and CHB patients with LC (1.04 +/- 0.31 mu g/mL, 1.12 +/- 0.34 mu g/mL, 1.51 +/- 0.43 mu g/mL respectively; p < 0.001). Serum AsAGP levels positively correlated with liver stiffness (r = 0.46, p < 0.001). AUROC of healthy control versus CHB with LC was 0.821 (p < 0.001, optimal cut-off 1.036 mu g/mL). AUROC of healthy control versus CHB was 0.624 (p = 0.049, optimal cut-off level 0.934 mu g/mL). AUROC of CHB versus CHB with LC was 0.765, (p < 0.001, optimal cut-off 1.260 mu g/mL). Conclusions Serum AsAGP levels in CHB patients with LC were significantly higher than those in healthy controls and CHB patients. AsAGP levels showed good diagnostic performance in predicting advanced fibrosis and cirrhosis, which suggests a potential role as a biomarker for predicting the progression of liver disease in CHB. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | MDPI AG | - |
dc.title | Diagnostic Efficacy of Serum Asialo alpha 1-Acid Glycoprotein Levels for Advanced Liver Fibrosis and Cirrhosis in Patients with Chronic Hepatitis B Compared to That in Healthy Subjects: A Prospective Study | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3390/jcm12020712 | - |
dc.identifier.scopusid | 2-s2.0-85146774280 | - |
dc.identifier.wosid | 000915182000001 | - |
dc.identifier.bibliographicCitation | Journal of Clinical Medicine, v.12, no.2 | - |
dc.citation.title | Journal of Clinical Medicine | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | ALPHA(1)-ACID GLYCOPROTEIN | - |
dc.subject.keywordPlus | HEPATOCELLULAR-CARCINOMA | - |
dc.subject.keywordPlus | NONINVASIVE ASSESSMENT | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | FIB-4 | - |
dc.subject.keywordPlus | CHOLINESTERASE | - |
dc.subject.keywordPlus | ELASTOGRAPHY | - |
dc.subject.keywordPlus | FUCOSYLATION | - |
dc.subject.keywordPlus | DISEASES | - |
dc.subject.keywordPlus | INDEX | - |
dc.subject.keywordAuthor | liver cirrhosis | - |
dc.subject.keywordAuthor | liver fibrosis | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | chronic hepatitis B | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
73, Goryeodae-ro, Seongbuk-gu, Seoul, Republic of Korea (02841)82-2-2286-1265
COPYRIGHT 2020 KOREA UNIVERSITY MEDICAL LIBRARY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.