Ultralow Background Near-Infrared Fluorophores with Dual-Channel Intraoperative Imaging Capability
- Authors
- Bao, Kai; Tully, Molly; Cardenas, Kevin; Wang, Haoran; Srinivas, Surbhi; Rho, Jiyun; Jeon, Ok Hwa; Dinh, Jason; Yokomizo, Shinya; McDonnell, Rose; Yamashita, Atsushi; Kashiwagi, Satoshi; Kang, Homan; Kim, Hyun Koo; Choi, Hak Soo
- Issue Date
- Jan-2023
- Publisher
- Wiley-Blackwell
- Keywords
- multispectral imaging; NIR imaging; renal clearance; targeted fluorophores; tumor targeting
- Citation
- Advanced Healthcare Materials, v.12, no.12
- Indexed
- SCIE
SCOPUS
- Journal Title
- Advanced Healthcare Materials
- Volume
- 12
- Number
- 12
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62391
- DOI
- 10.1002/adhm.202203134
- ISSN
- 2192-2640
2192-2659
- Abstract
- Two of the most pressing challenges facing bioimaging are nonspecific uptake of intravenously administered contrast agents and incomplete elimination of unbound targeted agents from the body. Designing a targeted contrast agent that shows fast clearance from background tissues and eventually the body after complete targeting is key to the success of image-guided interventions. Here, this work describes the development of renally clearable near-infrared contrast agents and their potential use for dual-channel image-guided tumor targeting. cRGD-ZW800-PEG (800 nm channel) and ZW700-PEG (700 nm channel) are able to visualize tumor margins and tumor vasculature simultaneously and respectively. These targeted agents show rapid elimination from the bloodstream, followed by renal clearance, which together significantly lower off-target background signals and potential toxicity. To demonstrate its applicability, this multispectral imaging is performed in various tumor-bearing animal models including lung cancer, pancreatic neuroendocrine tumors, breast, and ovarian cancer.
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- Appears in
Collections - 2. Clinical Science > Department of Thoracic and Cardiovascular Surgery > 1. Journal Articles
- 3. Graduate School > Graduate School > 1. Journal Articles
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