Comprehensive lipid profiles investigation reveals host metabolic and immune alterations during anti-tuberculosis treatment: Implications for therapeutic monitoringopen access
- Authors
- Anh, Nguyen Ky; Phat, Nguyen Ky; Yen, Nguyen Thi Hai; Jayanti, Rannissa Puspita; Thu, Vo Thuy Anh; Park, Young Jin; Cho, Yong-Soon; Shin, Jae-Gook; Kim, Dong Hyun; Oh, Jee Youn; Long, Nguyen Phuoc
- Issue Date
- Feb-2023
- Publisher
- Elsevier Masson
- Keywords
- Tuberculosis; Biomarker; Metabolic alteration; Lipidomics; Treatment monitoring; Immune response
- Citation
- Biomedicine and Pharmacotherapy, v.158
- Indexed
- SCIE
SCOPUS
- Journal Title
- Biomedicine and Pharmacotherapy
- Volume
- 158
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62395
- DOI
- 10.1016/j.biopha.2022.114187
- ISSN
- 0753-3322
1950-6007
- Abstract
- In this study, we investigated the lipidome of tuberculosis patients during standard chemotherapy to discover biosignatures that could aid therapeutic monitoring. UPLC-QToF MS was used to analyze 82 baseline and treatment plasma samples of patients with pulmonary tuberculosis. Subsequently, a data-driven and knowledge-based workflow, including robust annotation, statistical analysis, and functional analysis, was applied to assess lipid profiles during treatment. Overall, the lipids species from 17 lipid subclasses were significantly altered by anti-tuberculosis chemotherapy. Cholesterol ester (CE), monoacylglycerols, and phosphatidylcholine (PC) were upregulated, whereas triacylglycerols, sphingomyelin, and ether-linked phosphatidylethanolamines (PE O-) were downregulated. Notably, PCs demonstrated a clear upward expression pattern during tuberculosis treatment. Several lipid species were identified as potential biomarkers for therapeutic monitoring, such as PC(42:6), PE(O-40:5), CE(24:6), and dihexosylceramide Hex2Cer(34:2;2 O). Functional and lipid gene enrichment analysis revealed alterations in pathways related to lipid metabolism and host immune responses. In conclusion, this study provides a foundation for the use of lipids as biomarkers for clinical management of tuberculosis.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Pulmonary, Allergy, and Critical Care Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.