Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infectionopen access
- Authors
- Jeong, Hye Won; Kim, Se-Mi; Jung, Min Kyung; Noh, Ji Yun; Yoo, Ji-Seung; Kim, Eun-Ha; Kim, Young-Il; Yu, Kwangmin; Jang, Seung-Gyu; Gil, Juryeon; Casel, Mark Anthony; Rare, Rollon; Choi, Jeong Ho; Kim, Hee-Sung; Kim, Jun Hyoung; Um, Jihye; Kim, Chaeyoon; Kim, Yeonjae; Chin, Bum Sik; Jung, Sungmin; Choi, Jun Yong; Song, Kyoung-Ho; Kim, Yong-Dae; Park, Jun-Sun; Song, Joon Young; Shin, Eui-Cheol; Choi, Young Ki
- Issue Date
- Oct-2022
- Publisher
- Elsevier
- Keywords
- ancestral; breakthrough infection; cross-neutralization; D614G; mRNA vaccine; Omicron BA.1; Omicron BA.2; recovered patient; SARS-CoV-2; T cell immune response; variants of concern
- Citation
- Cell Reports Medicine, v.3, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- Cell Reports Medicine
- Volume
- 3
- Number
- 10
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62411
- DOI
- 10.1016/j.xcrm.2022.100764
- ISSN
- 2666-3791
- Abstract
- Omicron has become the globally dominant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant, creating additional challenges due to its ability to evade neutralization. Here, we report that neutralizing antibodies against Omicron variants are undetected following COVID-19 infection with ancestral or past SARS-CoV-2 variant viruses or after two-dose mRNA vaccination. Compared with two-dose vaccination, a three-dose vaccination course induces broad neutralizing antibody responses with improved durability against different SARS-CoV-2 variants, although neutralizing antibody titers against Omicron remain low. Intriguingly, among individuals with three-dose vaccination, Omicron breakthrough infection substantially augments serum neutralizing activity against a broad spectrum of SARS-CoV-2 variants, including Omicron variants BA.1, BA.2, and BA.5. Additionally, after Omicron breakthrough infection, memory T cells respond to the spike proteins of both ancestral and Omicron SARS-CoV-2 by producing cytokines with polyfunctionality. These results suggest that Omicron breakthrough infection following three-dose mRNA vaccination induces pan-SARS-CoV-2 immunity that may protect against emerging SARS-CoV-2 variants of concern.
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- Appears in
Collections - 2. Clinical Science > Department of Infectious Diseases > 1. Journal Articles
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