Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Association Between Smoking Cessation and the Risk of Cholangiocarcinoma and Ampulla of Vater Cancer: A Nationwide Cohort Studyopen access

Authors
Park, Joo-HyunHong, Jung YongHan, Kyungdo
Issue Date
2023
Publisher
ALLSCHWILERSTRASSE 10, BASEL, SWITZERLAND, CH-4009
Citation
LIVER CANCER
Indexed
SCIE
SCOPUS
Journal Title
LIVER CANCER
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62538
DOI
10.1159/000529609
ISSN
2235-1795
1664-5553
Abstract
Introduction The association between smoking cessation and intrahepatic and extrahepatic cholangiocarcinoma (iCCA and eCCA) risk is unclear. Furthermore, the association in individuals with preexisting risk factors is unknown. We aimed to investigate the association between smoking status (especially smoking cessation) and CCA risk according to individuals' glycemic status. Methods In this nationwide cohort study, 9,520,629 adults without cancer who underwent national health screening by the Korean National Health Insurance Service in 2009 were followed up through 2018. The hazard ratios (HRs) and 95% confidence intervals (CIs) for CCA were estimated after adjusting for potential confounders. Results During the 78.3 person-years of follow-up, 16,236 individuals were newly diagnosed with CCA. Quitters had a significantly lower risk of iCCA and eCCA compared to current smokers in all glycemic status groups (all P<0.01). The HRs (95% CIs) for iCCA in current smokers and quitters were 1.33 (1.24-1.43) vs. 0.98 (0.90-1.06) in individuals with normoglycemia, 1.49 (1.37-1.63) vs. 1.17 (1.06-1.28) in individuals with prediabetes, and 2.15 (1.96-2.37) vs. 1.58 (1.42-1.75) in individuals with diabetes, compared to never-smokers with normoglycemia. Current smokers with diabetes or prediabetes had a synergistically increased risk of iCCA (all P<0.01). However, quitters with diabetes and prediabetes had an iCCA risk comparable to that of never-smokers. Analysis of eCCA yielded similar results. Smoking was not independently associated with the risk of the ampulla of Vater cancer. However, smoking combined with diabetes or prediabetes was associated with an increased risk of the ampulla of Vater cancer (all P<0.05). Discussion/Conclusion Smoking cessation was associated with a reduced risk of CCA, despite the synergistically increased risk in current smokers with diabetes and prediabetes. Our findings suggest a crucial opportunity to reduce the risk of CCA. More individualized and intensive cancer prevention education is needed against CCA.
Files in This Item
There are no files associated with this item.
Appears in
Collections
2. Clinical Science > Department of Family Medicine > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Joo Hyun photo

Park, Joo Hyun
Ansan Hospital (Department of Family Medicine, Ansan Hospital)
Read more

Altmetrics

Total Views & Downloads

BROWSE