Association between Low-Density Lipoprotein Cholesterol Level and Cardiovascular Outcomes in Korean Adults: A Nationwide Cohort Studyopen access
- Authors
- Noh, Junghyun; Moon, Min Kyong; Rhee, Eun-Jung; Park, Sang Hyun; Kim, Hyeon Chang; Kim, Byung Jin; Kim, Hae Jin; Choi, Seonghoon; Na, Jin Oh; Hyun, Young Youl; Kim, Bum Joon; Han, Kyung-Do; Jeong, In-Kyung
- Issue Date
- Jan-2023
- Publisher
- 대한당뇨병학회
- Keywords
- Cardiovascular diseases; Cholesterol; LDL; Korea
- Citation
- Diabetes and Metabolism Journal, v.47, no.1, pp 59 - 71
- Pages
- 13
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Diabetes and Metabolism Journal
- Volume
- 47
- Number
- 1
- Start Page
- 59
- End Page
- 71
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62595
- DOI
- 10.4093/dmj.2021.0320
- ISSN
- 2233-6079
2233-6087
- Abstract
- Background
To validate the treatment target of low-density lipoprotein cholesterol (LDL-C) level according to the cardiovascular disease (CVD) risk which was recommended by Korean dyslipidemia guideline.
Methods
We used the Korean National Health Insurance Service database which included 3,958,048 people aged 20 to 89 years who underwent regular health screening. The primary outcome was incident CVD, defined as a composite of myocardial infarction and stroke during the follow-up period from 2009 to 2018.
Results
The risk of CVD increased from LDL-C level of 70 mg/dL in very high-risk and high-risk groups and from 130 mg/dL in moderate-risk and low-risk groups. Adjusted hazard ratios (HRs) of LDL-C ranges 70-99, 100-129, 130-159, 160-189, and ≥190 mg/dL were 1.20 (95% confidence interval [CI], 1.08-1.33), 1.27 (1.15-1.42), 1.39 (1.23-1.56), 1.69 (1.45-1.96), and 1.84 (1.49- 2.27) in very high-risk group, and 1.07 (1.02-1.13), 1.16 (1.10-1.21), 1.29 (1.22-1.36), 1.45 (1.36-1.55), and 1.73 (1.58-1.90) in high-risk group. Adjusted HRs (95% CI) of LDL-C ranges 130-159, 160-189, and ≥190 mg/dL were 1.15 (1.11-1.20), 1.28 (1.22- 1.34), and 1.45 (1.36-1.54) in moderate-risk group and 1.07 (1.02-1.13), 1.20 (1.13-1.26), and 1.47 (1.37-1.57) in low-risk group.
Conclusion
We confirmed the incidence of CVD was increased in higher LDL-C range. The risk of CVD increased from ≥70 mg/dL of LDL-C in very high-risk and high-risk groups, and from ≥130 mg/dL of LDL-C in moderate-risk and low-risk groups in Korean adults.
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Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
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