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The Impact of Persistent Low Weight Status on the Occurrence of Vertebral Fractures: A Nationwide Population-Based Cohort Studyopen accessThe Impact of Persistent Low Weight Status on the Occurrence of Vertebral Fractures: A Nationwide Population-Based Cohort Study

Other Titles
The Impact of Persistent Low Weight Status on the Occurrence of Vertebral Fractures: A Nationwide Population-Based Cohort Study
Authors
Park, Sang-MinPark, JiwonHan, SangsooJang, Hae-DongHong, Jae-YoungHan, KyungdoKim, Ho-JoongYeom, Jin S.
Issue Date
Feb-2023
Publisher
대한의학회
Keywords
Claim Database; Vertebral Fracture; Osteoporosis; Underweight
Citation
Journal of Korean Medical Science, v.38, no.7, pp 1 - 13
Pages
13
Indexed
SCIE
SCOPUS
KCI
Journal Title
Journal of Korean Medical Science
Volume
38
Number
7
Start Page
1
End Page
13
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62696
DOI
10.3346/jkms.2023.38.e48
ISSN
1011-8934
1598-6357
Abstract
Background Although, being underweight is commonly associated with osteoporosis and sarcopenia, its association with vertebral fractures (VFs), is less well researched. We investigated the influence of cumulative, chronic periods of low weight and changes in body weight on VF development. Methods We used a nationwide, population-based database with data on people (> 40 years) who attended three health screenings between January 1, 2007, and December 31, 2009 to assess the incidence of new VFs. Cox proportional hazard analyses were used to establish the hazard ratios (HRs) for new VFs based on the degree of body mass index (BMI), the cumulative numbers of underweight participants, and temporal change in weight. Results Of the 561,779 individuals in this analysis, 5,354 (1.0%) people were diagnosed three times, 3,672 (0.7%) were diagnosed twice, and 6,929 (1.2%) were diagnosed once. The fully adjusted HR for VFs in underweight individuals was 1.213. Underweight individuals diagnosed only once, twice, or three times had an adjusted HR of 0.904, 1.443, and 1.256, respectively. Although the adjusted HR was higher in adults who were consistently underweight, there was no difference in those who experienced a temporal change in body weight. BMI, age, sex, and household income were significantly associated with VF incidence. Conclusion Low weight is a risk factor for VFs in the general population. Given the significant correlation between cumulative periods of low weight and the risk of VFs, it is necessary to treat underweight patients before a VF to prevent its development and other osteoporotic fractures.
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Park, Ji Won
Ansan Hospital (Department of Orthopedic Surgery, Ansan Hospital)
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