Minimal dose of hematopoietic stem cell transplantation without myelosuppressive conditioning for T-B plus NK- severe combined immunodeficiency
- Authors
- Yi, Eun Sang; Ju, Hee Young; Cho, Hee Won; Lee, Ji Won; Sung, Ki Woong; Koo, Hong Hoe; Kang, Eun-Suk; Ahn, Kang Mo; Kim, Yae-Jean; Yoo, Keon Hee
- Issue Date
- Mar-2023
- Publisher
- Academic Press
- Keywords
- Hematopoietic stem cell transplantation; Severe combined immunodeficiency; Primary immune deficiency; Cell count; Children
- Citation
- Clinical Immunology, v.248
- Indexed
- SCIE
SCOPUS
- Journal Title
- Clinical Immunology
- Volume
- 248
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62761
- DOI
- 10.1016/j.clim.2023.109269
- ISSN
- 1521-6616
1521-7035
- Abstract
- We reviewed the medical records of five patients with T-B+NK-severe combined immunodeficiency (SCID) who received minimal dose allogeneic hematopoietic cell transplantation (HCT) (total nucleated cell count (TNC) lower than 1.0 x 108/kg). Patients were administered a median of 5.0 mL of bone marrow or peripheral blood without conditioning (in four) or with anti-thymocyte globulin alone (in one). Three patients received HCT from a matched sibling donor, one from unrelated donor, and one from familial mismatched donor. The median TNC and CD34+ cells were 0.54 (0.29-0.84) x 108/kg and 0.61 (0.35-0.84) x 106/kg, respectively. Engraftment was achieved in all. Total T cell, CD4+ cell, and CD8+ cell recovery was obtained within a year in four, and immunoglobulin replacement was discontinued in all. All patients survived, exhibiting stable donor chimerism. We obtained sufficient therapeutic effects with minimal dose transplantation without intensive conditioning in patients with T-B+NK-SCID.
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- Appears in
Collections - 2. Clinical Science > Department of Pediatrics > 1. Journal Articles
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