Circulating leptin and its correlation with rheumatoid arthritis activity: a meta-analysisopen access
- Authors
- Lee, Young Ho; Song, Gwan Gyu
- Issue Date
- Apr-2023
- Publisher
- 대한류마티스학회
- Keywords
- Leptin; Rheumatoid arthritis; Meta-analysis
- Citation
- Journal of Rheumatic Diseases, v.30, no.2, pp 116 - 125
- Pages
- 10
- Indexed
- SCOPUS
ESCI
KCI
- Journal Title
- Journal of Rheumatic Diseases
- Volume
- 30
- Number
- 2
- Start Page
- 116
- End Page
- 125
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62933
- DOI
- 10.4078/jrd.2023.0005
- ISSN
- 2093-940X
2233-4718
- Abstract
- Objective
The aim of the study was to investigate the association between the levels of leptin in the circulating of individuals with rheumatoid arthritis (RA) and the severity of the disease.
Methods
We looked through the databases of Embase, Medline, and the Cochrane Library. We conducted a meta-analysis on the correlations between circulating leptin and the Disease Activity Score 28-erythrocyte sedimentation rate (DAS28-ESR) and C-reactive protein (CRP) levels in RA patients, as well as a meta-analysis of circulating or circulating leptin levels in RA patients.
Results
This meta-analysis study analyzed 42 different comparisons from 37 different publications, including a total of 2,350 patients with RA and 1,815 controls. The RA group had substantially higher leptin levels than the control group (standardized mean difference [SMD]=0.507, 95% confidence interval [CI]=0.309~0.704, p<0.001). The finding that RA patients had higher leptin levels was unaffected by sample size. The correlation between circulating leptin levels and DAS28 is statistically significant (correlation coefficient=0.247, 95% CI=0.087~0.396, p=0.003). Leptin levels are also correlated with CRP levels (correlation coefficient= 0.203, 95% CI=0.048~0.349, p=0.010).
Conclusion
This comprehensive meta-analysis demonstrates that the circulating leptin levels of RA patients are elevated, and provides compelling evidence of the significant relationship between leptin levels and the activity of RA. The findings of this research suggest that leptin plays a significant role in the pathophysiology of this disease.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 2. Clinical Science > Department of Rheumatology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.