Incidence of Cardiovascular Disease After Atopic Dermatitis Development: A Nationwide, Population-Based Study
- Authors
- Lee, Seung Won; Kim, Hayeon; Byun, Youngjoo; Baek, Yoo Sang; Choi, Cheol Ung; Kim, Jae Hyun; Kim, Kyungim
- Issue Date
- Mar-2023
- Publisher
- 대한천식알레르기학회
- Keywords
- Atopic dermatitis; eczema; cardiovascular disease; myocardial ischemia; stroke
- Citation
- Allergy, Asthma & Immunology Research, v.15, no.2, pp 231 - 245
- Pages
- 15
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Allergy, Asthma & Immunology Research
- Volume
- 15
- Number
- 2
- Start Page
- 231
- End Page
- 245
- URI
- https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/62964
- DOI
- 10.4168/aair.2023.15.2.231
- ISSN
- 2092-7355
2092-7363
- Abstract
- Purpose
Despite increasing evidence for the potential association between atopic dermatitis (AD) and cardiovascular diseases (CVDs), results have still remained controversial. Therefore, this study investigated the association between AD and subsequent CVDs in adults newly diagnosed with AD.
Methods
Datasets from the National Health Insurance Service-National Sample Cohort in South Korea from 2002 to 2015 were analyzed. The primary outcome was new-onset CVD, which included angina pectoris, myocardial infarction, stroke, or any revascularization procedure. The crude and adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were estimated in the AD group compared with the matched control group using the Cox proportional hazards regression models.
Results
A total of 40,512 individuals with AD were matched with 40,512 control subjects without AD. The overall incidence of CVDs was 2,235 (5.5%) and 1,640 (4.1%) in the AD and matched control groups, respectively. In the adjusted model, AD was associated with an increased risk of CVDs (HR, 1.42; 95% CI, 1.33–1.52), angina pectoris (adjusted HR, 1.49; 95% CI, 1.36–1.63), myocardial infarction (adjusted HR, 1.40; 95% CI, 1.15–1.70), ischemic stroke (adjusted HR, 1.34; 95% CI, 1.20–1.49), and hemorrhagic stroke (adjusted HR, 1.26; 95% CI, 1.05–1.52). Most of the subgroup and sensitivity analysis results were consistent with those of the main analysis.
Conclusions
The current study found that adult patients newly diagnosed with AD were at significantly increased risk for subsequent CVDs, suggesting the need to consider early prevention strategies for CVDs targeting patients with AD.
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- Appears in
Collections - 2. Clinical Science > Department of Cardiology > 1. Journal Articles
- 2. Clinical Science > Department of Dermatology > 1. Journal Articles
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