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Taltirelin Hydrate in Patients with Ataxia Due to Spinocerebellar Degenerationopen access

Authors
Cho, Jin WhanLee, Jee-YoungKim, Han-JoonKim, Joong-SeokPark, Kun-WooChoi, Seong-MinLyoo, Chul HyoungKoh, Seong-Beom
Issue Date
Oct-2025
Publisher
대한파킨슨병및이상운동질환학회
Keywords
Hereditary ataxia; Speech; Spinocerebellar Degenerations; Stance; Taltirelin hydrate
Citation
Journal Of Movement Disorders
Indexed
SCIE
SCOPUS
KCI
Journal Title
Journal Of Movement Disorders
URI
https://scholarworks.korea.ac.kr/kumedicine/handle/2021.sw.kumedicine/75731
DOI
10.14802/jmd.24127
ISSN
2005-940X
2093-4939
Abstract
We conducted this study to assess the efficacy and safety of taltirelin hydrate (TH) in spinocerebellar degeneration (SCD). Patients were randomly assigned to either the taltirelin group (5 mg orally, twice daily) or the control group. The primary endpoint was changes in the Korean version of Scale for the Assessment and Rating of Ataxia (K-SARA) scores at 24 weeks. The secondary endpoints include changes in the K-SARA scores at 4 and 12 weeks, the Clinical Global Impression, Five-level version of the EuroQol five-dimensional questionnaire, Tinetti balance test and gait analysis at 4, 12 and 24 weeks. A total of 149 patients (hereditary:non-hereditary = 86:63) were enrolled. There were significant differences in changes in K-SARA scores at 24 weeks from baseline between the taltirelin group and the control group (-0.51 ± 2.79 versus 0.36 ± 2.62, respectively; p = 0.0321). Of the K-SARA items, both 'Stance' and 'Speech disturbance' had significantly lower subscores in the taltirelin group as compared with the control group (-0.04 ± 0.89 versus 0.23 ± 0.79 and -0.07 ± 0.74 versus 0.18 ± 0.67; p = 0.0270 and 0.0130, respectively). But there were no significant differences in changes in other secondary efficacy outcome measures at 24 weeks from baseline between the two treatment arms (p > 0.05). Clinicians might consider using TH in the treatment of ataxia due to SCD.
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Koh, Seong Beom
Guro Hospital (Department of Neurology, Guro Hospital)
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