Effects of alpha 1- and alpha-2-adrenoreceptor antagonists on cold allodynia in a rat tall model of neuropathic pain

Kim, SK; Min, BI; Kim, JH; Hwang, BG; Yoo, GY; Park, DS; Na, HS

doi:10.1016/j.brainres.2005.01.051

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Effects of alpha 1- and alpha-2-adrenoreceptor antagonists on cold allodynia in a rat tall model of neuropathic pain

Kim, SK;
Min, BI;
Kim, JH;
Hwang, BG;
Yoo, GY;
... Na, HS;
외 1명

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25

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26

초록

Systemic administrations (0.1, 0.5, and 2 mg/kg) of alpha 1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas alpha 2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of alpha 1- and alpha 2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by alpha 1-AR antagonist and exacerbated by alpha 2-AR antagonist. (c) 2005 Elsevier B.V. All rights reserved.

키워드

neuropathic pain; cold allodynia; prazosin; yohimbine; alpha 1-adrenoreceptor; alpha 2-adrenoreceptor; PERIPHERAL-NERVE INJURY; ADRENERGIC SENSITIVITY; EXPERIMENTAL MONONEUROPATHY; THERMAL HYPERALGESIA; SYMPATHECTOMY; RECEPTORS; CONSTRICTION; EXCITATION; LIGATION; BEHAVIOR

제목: Effects of alpha 1- and alpha-2-adrenoreceptor antagonists on cold allodynia in a rat tall model of neuropathic pain

저자: Kim, SK; Min, BI; Kim, JH; Hwang, BG; Yoo, GY; Park, DS; Na, HS

DOI: 10.1016/j.brainres.2005.01.051

발행일: 2005-03-28

유형: Article

저널명: Brain Research

권: 1039

호: 1-2

페이지: 207 ~ 210

언어: ENG

출판사: Elsevier BV

발행국가: 네덜란드

분량: 4 페이지

ISSN: E 1872-6240
P 0006-8993