Vitamin E가 正常人 保存血液 및 生體內 赤血球脆弱性에 미치는 影響에 關한 硏究

초록

The effects of vitamin E, parenteral administration and supplement in vitro to human blood-its components and osmotic resistance-were studied. Blood samples were collected from 12 normal abult volunteers and afterward vitamin E was administered on a daily dose of 200 I.U. for 90 days. In vitro test, 0.1 ㎎ of dl-alpha-tocopheryl acetate was added on each ml of blood specimens. Hematological values were calculated and osmotic fragiljty was measured by Dacie's method for 25 days at 5-day intervals. The following results were obtained. 1. It was observed that vitamin E supplement in human ACD-blood in storage at 4℃ Greatly retarded the rate of decrease in osmotic resistance of erythrocytes. 2. RBC fragility was sensitive to temperature that exposure at 37℃ For 6 hours accelerated the hemolysis and it was markedly suppressed by vitamin E supplement. 3. Parenteral adminstration of vitamin E resulted in increased values for total red cell counts, hemoglobin, hematocrit and reticulocytes, while platelet counts were decreased comparing with observed. 4. Therefore, it is emphasized that vitamin E supplement into the stored blood in definitely effective to red cell survival and it is recommendable for the blood storing in long term preservation especially under the inadequate temperature.

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