p53 codon 72 polymorphism and rheumatoid arthritis

초록

Objective. To investigate whether the p53 codon 72 polymorphism is associated with susceptibility to rheumatoid arthritis (RA) and its clinical features. Methods. A polymerase chain reaction of genomic DNA-restriction fragment length polymorphism was used to determine genotypes of the p53 codon 72 in 114 patients with RA and 114 healthy controls. Clinical/serological manifestations were analyzed in each patient and correlated with the genotypes. Results. The genotype distribution of the p53 codon 72 did not differ between patients with RA and controls (Arg/Arg, Arg/Pro, Pro/Pro genotypes 38, 58, 18 vs 37, 60, 17 controls, respectively; chi-square = 0.08, 2 df, p = 0.96). No significant difference was found in allele frequencies between the groups. Clinically there was no significant difference in age at onset, functional class, physician's global assessment. ESR, CRP, RF titer, extraarticular and cervical spine involvement, frequencies of joint operation. and admission in RA patients according to the p53 codon 72 genotypes. However, the number of patients within each group was extremely small, for example only 5 patients with cervical spine involvement. No firm conclusions could safety be reached about clinical manifestations from this study. Conclusion. No association was found between the p53 codon 72 polymorphism and RA. Studies are needed to clarify the role of the p53 polymorphism in the pathogenesis of RA.

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