Highly Stretchable Microelectrode Array for Free-form 3D Neuronal Tissue

Shim, Chaeyun; Jo, Yehhyun; Cha, Hyo Kyeong; Kim, Mi Kyung; Kim, Hyojung; Kook, Geon; Kim, Kiup; Son, Gi Hoon; Lee, Hyunjoo J

doi:10.1109/MEMS46641.2020.9056250

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Highly Stretchable Microelectrode Array for Free-form 3D Neuronal Tissue

Shim, Chaeyun;
Jo, Yehhyun;
Cha, Hyo Kyeong;
Kim, Mi Kyung;
Kim, Hyojung;
... Son, Gi Hoon;
외 3명

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초록

There has been rapid advancement in the development of 3D neuronal cultures and brain organoids. However, conventional rigid 2D and 3D microelectrode arrays (MEAs) are not suitable for neural recording of free-form tissues due to limited contact with the tissue and poor media exchange. Here, we present a stretchable dual-MEA device suitable for non-invasive recording of free-form neural tissues for the first time. We achieve high stretchability by employing serpentine signal lines on a polyimide substrate and enable media exchange through perforated regions. A tissue sample was placed in between a pair of these stretchable MEAs to demonstrate successful 3D conformal contact and continuous media exchange. © 2020 IEEE.

키워드

Organoid; 3D tissue; stretchable electronics; microelectrode array (MEA); signal recording; High energy physics; Histology; Mechanics; MEMS; Microelectrodes; Microstrip lines; Serpentine; 3-D microelectrode arrays; 3-D neuronal cultures; Conformal contacts; Microelectrode array; Neural recordings; Neuronal tissues; Non-invasive recording; Polyimide substrate; Tissue

제목: Highly Stretchable Microelectrode Array for Free-form 3D Neuronal Tissue

저자: Shim, Chaeyun; Jo, Yehhyun; Cha, Hyo Kyeong; Kim, Mi Kyung; Kim, Hyojung; Kook, Geon; Kim, Kiup; Son, Gi Hoon; Lee, Hyunjoo J

DOI: 10.1109/MEMS46641.2020.9056250

발행일: 2020-01

유형: Proceedings Paper

저널명: Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)

페이지: 380 ~ 383

언어: ENG

분량: 4 페이지

ISSN: P 1084-6999