Influences of reserpine and cocaine on the changes of brain norepinephrine content and plasma corticosterone level induced by ketamine

초록

The influences of reserpine and cocaine on the changes of brain and cardiac norepinephrine (NE) contents and plasma corticosterone level induced by ketamine in mice were studied. The results obtained were summarized as follow: Various doses (5 mg, 10 mg, 20 mg and 40 mg/kg) of ketamine gradually increased the plasma corticosterone levels in 30 minutes, especially 20 mg/kg and 40 mg/kg dose treatments markedly increased the levels. Brain and cardiac NE contents were decreased in 30 minutes and 60 minutes after ketamine treatment. The plasma corticosterone level induced by ketamine was decreased by reserpine pretreatment (36 hr.) but not by cocaine pretreatment (15 min.). Brain and cardiac NE contents induced by ketamine were decreased by reserpine pretreatment, but increased by cocaine pretreatment.

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