구강 작열감 증후군에서 국소 항진균제의 치료 효과

초록

Background and Objectives Burning mouth syndrome (BMS) is a poorly understood diseasethat is characterized by burning pain of the tongue without any identifiable organic disease. The pathophysiology of the disease has not been elucidated, and some kind of neuropathiesare suspected to be involved. In this study, topical antifungals were prescribed to patientsand the authors tried to evaluate its efficacy to BMS. Subjects and Method 166 patients who had been diagnosed with burning mouth syndromeunderwent topical antifungals treatment alone, and then follow-up at 2, 6, and 10 weeks of treatment. Effectiveness of treatment was evaluated by a 0-to-4 verbal rating scale. All enrolled patientshad fungus culture in the oral cavity. Results A total of 103 patients responded to treatment, accounting for 62% of the patients. Of those, a total of 63 patients were positive for the fungal culture, which was about 38% ofthe patients. There was a statistically significant difference between the initial pain assessmentand the pain assessment after 10 weeks in all patients. The rate of response to treatmentwas not significantly different when classified according to patients’ characteristics and comorbidities. Conclusion The result of the study suggests that topical antifungals are useful for BMS andthat it can be used in addition to the systemic medication without the burden of side effects. Additional well-designed studies should be followed to prove the effectiveness of topical antifungalsand research on pathophysiology of the disease.

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